A minor capsid protein P30 is essential for bacteriophage PRD1 capsid assembly

被引：43
|
作者：
Rydman, PS
Bamford, JKH
Bamford, DH
机构：
[1] Univ Helsinki, Viikki Bioctr, Dept Biosci, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Viikki Bioctr, Inst Biotechnol, FIN-00014 Helsinki, Finland
来源：
JOURNAL OF MOLECULAR BIOLOGY | 2001年 / 313卷 / 04期
基金：
芬兰科学院;
关键词：
virus assembly; virus structure; membrane biogenesis; bacteriophage PRD1; capsid stability;
D O I：
10.1006/jmbi.2001.5068
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bacteriophage PRD1 is a double-stranded DNA virus infecting Gram-negative hosts. It has a membrane component located in the interior of the isometric capsid. In addition to the major capsid protein P3, the capsid contains a 9 kDa protein P30. Protein P30 is proposed to be located between the adjacent facets of the icosahedral capsid and is required for stable capsid assembly. In its absence, an empty phage-specific membrane vesicle is formed. The major protein component of this vesicle is a phage-encoded assembly factor, protein P10, that is not present in the final structure. (C) 2001 Academic Press.
引用
收藏
页码：785 / 795
页数：11
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