The current status, challenges, and future developments of new tuberculosis vaccines

被引：78

作者：

Gong, Wenping ^{[1
]}

Liang, Yan ^{[1
]}

Wu, Xueqiong ^{[1
]}

机构：

[1] Inst TB Res, Beijing Key Lab New Tech TB Diag & Treatment, Army TB Prevent & Control Key Laboratory, 309th Hosp Chinese PLA,17 Heishanhu Rd, Beijing 100091, Peoples R China

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2018年 / 14卷 / 07期

关键词：

BCG; Clinical trials; Immunology; Mycobacterium tuberculosis; Tuberculosis; Vaccines; BACILLUS-CALMETTE-GUERIN; BCG COEXPRESSING AG85B; MYCOBACTERIUM-INDICUS-PRANII; MEDIATED IMMUNE-RESPONSE; ENHANCED CELLULAR IMMUNE; CHIMERIC DNA VACCINE; PROTECTIVE EFFICACY; FUSION PROTEIN; SUBUNIT VACCINE; TB VACCINE;

D O I：

10.1080/21645515.2018.1458806

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mycobacterium tuberculosis complex causes tuberculosis (TB), one of the top 10 causes of death worldwide. TB results in more fatalities than multi-drug resistant (MDR) HIV strain related coinfection. Vaccines play a key role in the prevention and control of infectious diseases. Unfortunately, the only licensed preventive vaccine against TB, bacilli Calmette-Guerin (BCG), is ineffective for prevention of pulmonary TB in adults. Therefore, it is very important to develop novel vaccines for TB prevention and control. This literature review provides an overview of the innate and adaptive immune response during M. tuberculosis infection, and presents current developments and challenges to novel TB vaccines. A comprehensive understanding of vaccines in preclinical and clinical studies provides extensive insight for the development of safer and more efficient vaccines, and may inspire new ideas for TB prevention and treatment.

引用

页码：1697 / 1716

页数：20

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