TB vaccines: current status and future perspectives

被引：62

作者：

Aagaard, Claus ^{[1
]}

Dietrich, Jes ^{[1
]}

Doherty, Mark ^{[1
]}

Andersen, Peter ^{[1
]}

机构：

[1] Statens Serum Inst, Dept Infect Dis Immunol, DK-2300 Copenhagen, Denmark

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2009年 / 87卷 / 04期

关键词：

tuberculosis; bacterial; vaccination; BCG; latency; MYCOBACTERIUM-TUBERCULOSIS INFECTION; BACILLUS-CALMETTE-GUERIN; DELAYED-TYPE HYPERSENSITIVITY; BOVIS BCG VACCINE; INTERFERON-GAMMA; PROTECTIVE IMMUNITY; SUBUNIT VACCINE; LATENT TUBERCULOSIS; IN-VITRO; ENVIRONMENTAL MYCOBACTERIA;

D O I：

10.1038/icb.2009.14

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Antigen discovery programs have exploited this and used proteome studies and T-cell recognition in PPD-positive individuals to select proteins and after testing for protective efficacy in animals the most promising proteins have been put together in fusion molecules. Three such fusion proteins are currently in clinical trials, the two most advanced have already passed phase I trials and are entering phase II. Immunology and Cell Biology ( 2009) 87, 279-286; doi:10.1038/icb.2009.14; published online 7 April 2009

引用

页码：279 / 286

页数：8

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