A New Electrochemical Sensor for Direct Detection of Purine Antimetabolites and DNA Degradation

被引：11
|
作者：
Shpigun, Liliya K. [1 ]
Andryukhina, Elena Yu. [1 ]
机构：
[1] Russian Acad Sci, Inst Gen & Inorgan Chem, Moscow 119991, Russia
来源：
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY | 2019年 / 2019卷
关键词：
SURFACE-CONFINED INTERACTION; NANOTUBES PASTE ELECTRODE; VOLTAMMETRIC DETERMINATION; LIQUID-CHROMATOGRAPHY; ANTICANCER DRUGS; GRAPHENE OXIDE; IONIC LIQUID; 6-MERCAPTOPURINE; 6-THIOGUANINE; AZATHIOPRINE;
D O I：
10.1155/2019/1572526
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The development of a reliable electrochemical sensor using a hybrid nanocomposite consisting of ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) functionalized graphene oxide (GrO-IL) and gold nanoparticles (AuNPs) stabilized by chitosan (Chit) was described. The new sensor, labelled as GrO-IL-AuNPs-Chit/CSE, exhibited an improved electrocatalytic response to cancer drugs such as purine antimetabolites (6-thioguanine, 6-mercaptopurine, and azathioprine) in a wide concentration range with a low detection limit (20-40nmol L -1, S/N=3), and satisfactory recoveries (97.1-103.0%). The sensor has been also successfully used for cyclic voltammetric study of a salmon sperm double-stranded DNA degradation and DNA-6-mercaptopurine interaction in aqueous solutions (pH 7.4).
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页数：8
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