A New Electrochemical Sensor for Direct Detection of Purine Antimetabolites and DNA Degradation

被引：11
|
作者：
Shpigun, Liliya K. [1 ]
Andryukhina, Elena Yu. [1 ]
机构：
[1] Russian Acad Sci, Inst Gen & Inorgan Chem, Moscow 119991, Russia
来源：
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY | 2019年 / 2019卷
关键词：
SURFACE-CONFINED INTERACTION; NANOTUBES PASTE ELECTRODE; VOLTAMMETRIC DETERMINATION; LIQUID-CHROMATOGRAPHY; ANTICANCER DRUGS; GRAPHENE OXIDE; IONIC LIQUID; 6-MERCAPTOPURINE; 6-THIOGUANINE; AZATHIOPRINE;
D O I：
10.1155/2019/1572526
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The development of a reliable electrochemical sensor using a hybrid nanocomposite consisting of ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) functionalized graphene oxide (GrO-IL) and gold nanoparticles (AuNPs) stabilized by chitosan (Chit) was described. The new sensor, labelled as GrO-IL-AuNPs-Chit/CSE, exhibited an improved electrocatalytic response to cancer drugs such as purine antimetabolites (6-thioguanine, 6-mercaptopurine, and azathioprine) in a wide concentration range with a low detection limit (20-40nmol L -1, S/N=3), and satisfactory recoveries (97.1-103.0%). The sensor has been also successfully used for cyclic voltammetric study of a salmon sperm double-stranded DNA degradation and DNA-6-mercaptopurine interaction in aqueous solutions (pH 7.4).
引用
收藏
页数：8
相关论文
共 50 条
  • [31] Advancements in electrochemical DNA sensor for detection of human papilloma virus - A review
    Rasouli, Elisa
    Shahnavaz, Zohreh
    Basirun, Wan Jefrey
    Rezayi, Majid
    Avan, Amir
    Ghayour-Mobarhan, Majid
    Khandanlou, Roshanak
    Johan, Mohd Rafie
    ANALYTICAL BIOCHEMISTRY, 2018, 556 : 136 - 144
  • [32] Rapid detection of different DNA analytes using a single electrochemical sensor
    Mills, Dawn M.
    Foguel, Marcos V.
    Martin, Christopher P.
    Trieu, Tiffany T.
    Kamar, Ola
    Calvo-Marzal, Percy
    Kolpashchikov, Dmitry M.
    Chumbimuni-Torres, Karin Y.
    SENSORS AND ACTUATORS B-CHEMICAL, 2019, 293 : 11 - 15
  • [33] Electrochemical DNA sensor-based strategy for sensitive detection of DNA demethylation and DNA demethylase activity
    Shen, Qingming
    Fan, Mengxing
    Yang, Yin
    Zhang, Hui
    ANALYTICA CHIMICA ACTA, 2016, 934 : 66 - 71
  • [34] Imprinted sol-gel electrochemical sensor for melamine direct recognition and detection
    Xu, Guilin
    Zhang, Hongli
    Zhong, Min
    Zhang, Tingting
    Lu, Xiaojing
    Kan, Xianwen
    JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2014, 713 : 112 - 118
  • [35] Direct Detection of Candida albicans with a Membrane Based Electrochemical Impedance Spectroscopy Sensor
    Kwasny, Dorota
    Tehrani, Sheida Esmail
    Almeida, Catarina
    Schjodt, Ida
    Dimaki, Maria
    Svendsen, Winnie E.
    SENSORS, 2018, 18 (07)
  • [36] Cu2O Based Electrochemical Sensor for Direct Glucose Detection
    Majzlikova, Petra
    Prasek, Jan
    Chomoucka, Jana
    Drbohlavova, Jana
    Pekarek, Jan
    Hrdy, Radim
    Hubalek, Jaromir
    Trnkova, Libuse
    2013 IEEE SENSORS, 2013, : 1534 - 1537
  • [37] Electrochemical and photoelectrochemical degradation of direct dyes
    Socha, A.
    Sochocka, E.
    Podsiadly, R.
    Sokolowska, J.
    COLORATION TECHNOLOGY, 2006, 122 (04) : 207 - 212
  • [38] Application in the damage of DNA by electrochemical DNA sensor
    Sun, XY
    Xu, C
    Liu, SH
    He, PG
    Fang, YZ
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 1998, 19 (09): : 1393 - 1396
  • [39] An Electrochemical DNA Sensor for p53 Tumor Suppressor Gene Detection
    Zhang, Jie
    Wan, Long
    Fan, Hao
    Liao, Fusheng
    2016 THE 3RD INTERNATIONAL CONFERENCE ON MECHATRONICS AND MECHANICAL ENGINEERING (ICMME 2016), 2017, 95
  • [40] DNA-Enabled Self-Resetting Electrochemical Sensor for microRNA Detection
    Yang, Xu
    Yu, Chenhong
    Yang, Bei
    Jiang, Chu
    Gao, Rui
    Li, Weiying
    Wang, Jianbang
    Zhang, Tao
    Liu, Huajie
    Liu, Dongsheng
    SMALL METHODS, 2025,
12345