Ring-closing metathesis in peptides

被引：36

作者：

Gleeson, Ellen C. ^{[1
]}

Jackson, W. Roy ^{[1
]}

Robinson, Andrea J. ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 39期

基金：

澳大利亚研究理事会;

关键词：

Peptides; Olefin metathesis; Ring-closing metathesis; Dicarba peptides; Cyclic constraints; BOWMAN-BIRK INHIBITOR; ORGANIZATION INDUCED SYNTHESIS; SELECTIVE OLEFIN METATHESIS; ALPHA-HELICAL PEPTIDES; DICARBA-ANALOGS; CHEMICAL-SYNTHESIS; CROSS-METATHESIS; AMINO-ACIDS; MACROCYCLIC PEPTIDES; RUTHENIUM CATALYSTS;

D O I：

10.1016/j.tetlet.2016.08.032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review highlights developments in the field of ring-closing metathesis applied to the synthesis of cyclic peptides. Special attention is focussed on the synthesis of dicarba peptides that mimic native cystine containing peptides. Recent advances in the field are discussed, including the stereoselective synthesis of carbon-bridged peptides and RCM in aqueous media. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved.

引用

页码：4325 / 4333

页数：9

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