Synthesis and antimicrobial activity of Schiff bases and 2-azetidinones derived from quinazolin-4(3H)-one

被引：42
|
作者：
Patel, Navin B. [1 ]
Patel, Jaymin C. [1 ]
机构：
[1] Veer Narmad S Gujarat Univ, Organ Res Lab, Dept Chem, Surat 395007, Gujarat, India
来源：
ARABIAN JOURNAL OF CHEMISTRY | 2011年 / 4卷 / 04期
关键词：
Antimicrobial activity; 2-Azetidinone; Quinazolinone; Schiff base; PHARMACOLOGICAL EVALUATION; ANTIBACTERIAL ACTIVITY; DERIVATIVES; AZETIDIN-2-ONES; ACID;
D O I：
10.1016/j.arabjc.2010.07.005
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 2-oxo-azetidinyl-quinazolin-4(3H)-ones 5a-k have been synthesized from Schiff bases 4a-k. Schiff bases were synthesized by condensation reaction of compound 3 with substituted aromatic aldehydes. The benzoxazinone 2 was prepared by the cyclization reaction of acid chloride 1 with 5-bromo anthranilic acid. Further reaction of bcnzoxazinone 2 with hydrazine hydrate yielded compound 3. The structures of synthesized compounds were elucidated on the basis of elemental analyses as well as IR and NMR spectral data. Schiff bases 4a-k and 2-azetidinones 5a-k were screened for antibacterial and antifungal activities in vitro. Compounds having chloro and methoxy group exhibited good antimicrobial activity. (C) 2010 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.
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收藏
页码：403 / 411
页数：9
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