Design, Synthesis and Antitumor Activities of 1,2,3-triazole-diethylene Glycol Tethered Isatin Dimers

被引：15

作者：

Fan, Yi-Lei ^{[1
]}

Huang, Zhong-Ping ^{[2
]}

Liu, Min ^{[3
]}

机构：

[1] Zhejiang Police Coll, Key Lab Drug Prevent & Control Technol Zhejiang P, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou, Zhejiang, Peoples R China

[3] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 12期

关键词：

IN-VITRO; BIOLOGICAL EVALUATION; DERIVATIVES; HYBRIDS;

D O I：

10.1002/jhet.3330

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 1,2,3-triazole-diethylene glycol tethered isatin dimers were designed, synthesized, and screened for their in vitro antitumor activities in this paper. All dimers showed promising activities against the tested HepG2, Hela, A549, DU145, SKOV3, MCF-7, and doxorubicin-resistant MCF-7 human cancer cell lines. The most active dimer 7g was >1.55 folds more potent than etoposide against all tested cell lines, warrant further investigation.

引用

页码：2990 / 2995

页数：6

共 50 条

[41] Design, Synthesis and In Vitro Anti-microbial Evaluation of Ethylene/Propylene-1H-1,2,3-Triazole-4-Methylene-tethered Isatin-coumarin Hybrids
Jin, Xiaohong
Xu, Yan
Yang, Xuhong
Chen, Xiuling
Wu, Minghu
Guan, Jianguo
Feng, Lianshun
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2017, 17 (29) : 3213 - 3218
[42] Azide-alkyne cycloaddition towards 1H-1,2,3-triazole-tethered gatifloxacin and isatin conjugates: Design, synthesis and in vitro anti-mycobacterial evaluation
Xu, Zhi
Song, Xu-Feng
Hu, Yuan-Qiang
Qiang, Min
Lv, Zao-Sheng
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 138 : 66 - 71
[43] 1,2,3-Triazole tethered acetophenones: Synthesis, bioevaluation and molecular docking study
Mubarak H.Shaikh
Dnyaneshwar D.Subhedar
Vijay M.Khedkar
Prakash C.Jha
Firoz A.Kalam Khan
Jaiprakash N.Sangshetti
Bapurao B.Shingate
ChineseChemicalLetters, 2016, 27 (07) : 1058 - 1063
[44] Synthesis and In Vitro Anti-Tumor, Anti-Mycobacterial and Anti-HIV Activities of Diethylene-Glycol-Tethered Bis-Isatin Derivatives
Li, Wei
Zhao, Shi-Jia
Gao, Feng
Lv, Zao-Sheng
Tu, Jun-Ying
Xu, Zhi
CHEMISTRYSELECT, 2018, 3 (36): : 10250 - 10254
[45] Synthesis and Biological Evaluation of 1,2,3-triazole tethered Pyrazoline and Chalcone Derivatives
Hussaini, Syed Mohammed Ali
Yedla, Poornachandra
Babu, Korrapati Suresh
Shaik, Thokhir B.
Chityal, Ganesh Kumar
Kamal, Ahmed
CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 88 (01) : 97 - 109
[46] 1,2,3-Triazole tethered acetophenones: Synthesis, bioevaluation and molecular docking study
Shaikh, Mubarak H.
Subhedar, Dnyaneshwar D.
Khedkar, Vijay M.
Jha, Prakash C.
Khan, Firoz A. Kalam
Sangshetti, Jaiprakash N.
Shingate, Bapurao B.
CHINESE CHEMICAL LETTERS, 2016, 27 (07) : 1058 - 1063
[47] Synthesis of novel 2-acetamidothiazoles tethered with 1,2,3-triazole and pyridine pharmacophores
Kaushik, Reena
Chand, Mahesh
Rashid, Mohd.
Jain, Subhash C.
HETEROATOM CHEMISTRY, 2018, 29 (04)
[48] Synthesis and Antitumor Activity of Erlotinib Derivatives Linked With 1,2,3-Triazole
Deng, Peng
Sun, Ge
Zhao, Jie
Yao, Kaitai
Yuan, Miaomiao
Peng, Lizeng
Mao, Longfei
FRONTIERS IN PHARMACOLOGY, 2022, 12
[49] Design, synthesis and antibacterial activity evaluation of moxifloxacin-amide-1,2,3-triazole-isatin hybrids
Gao, Feng
Ye, Lei
Kong, Fangong
Huang, Gang
Xiao, Jiaqi
BIOORGANIC CHEMISTRY, 2019, 91
[50] Azide-Alkyne Cycloaddition En Route to 1H-1,2,3-Triazole-Tethered Isatin-Ferrocene, Ferrocenylmethoxy-Isatin, and Isatin-Ferrocenylchalcone Conjugates: Synthesis and Antiproliferative Evaluation
Singh, Amandeep
Saha, Sourav Taru
Perumal, Shanen
Kaur, Mandeep
Kumar, Vipan
ACS OMEGA, 2018, 3 (01): : 1263 - 1268

← 1 2 3 4 5 →