Design, Synthesis and Antitumor Activities of 1,2,3-triazole-diethylene Glycol Tethered Isatin Dimers

被引：15
|
作者：
Fan, Yi-Lei [1 ]
Huang, Zhong-Ping [2 ]
Liu, Min [3 ]
机构：
[1] Zhejiang Police Coll, Key Lab Drug Prevent & Control Technol Zhejiang P, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 12期
关键词：
IN-VITRO; BIOLOGICAL EVALUATION; DERIVATIVES; HYBRIDS;
D O I：
10.1002/jhet.3330
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel 1,2,3-triazole-diethylene glycol tethered isatin dimers were designed, synthesized, and screened for their in vitro antitumor activities in this paper. All dimers showed promising activities against the tested HepG2, Hela, A549, DU145, SKOV3, MCF-7, and doxorubicin-resistant MCF-7 human cancer cell lines. The most active dimer 7g was >1.55 folds more potent than etoposide against all tested cell lines, warrant further investigation.
引用
收藏
页码：2990 / 2995
页数：6
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