SB-497115, a novel, oral, small molecule thrombopoietin receptor agonist, increases platelet counts in healthy subjects

被引:0
|
作者
Jenkins, JM
Williams, D
Collins, DA
Deng, Y
Kitchen, V
Erickson-Miller, C
机构
[1] GlaxoSmithKline R&D, Collegeville, PA USA
[2] GlaxoSmithKline R&D, Res Triangle Pk, NC USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
105
引用
收藏
页码:64 / 65
页数:2
相关论文
共 44 条
  • [1] SB-497115, a novel, oral platelet growth factor, increases platelet counts in healthy subjects
    Jenkins, J.
    Williams, D.
    Collins, D. A.
    Deng, Y.
    Kitchen, V.
    Uhl, J.
    Erickson-Miller, C.
    EJC SUPPLEMENTS, 2005, 3 (02): : 420 - 420
  • [2] SB-497115, a novel, oral platelet growth factor, increases platelet counts in healthy subjects
    Jenkins, JM
    Williams, D
    Collins, DA
    Uhl, J
    Deng, Y
    Kitchen, V
    Erickson-Miller, C
    TRANSFUSION, 2005, 45 (03) : 1A - 1A
  • [3] An oral, non-petide, small molecule thrombopoietin receptor agonist increases platelet counts in healthy subjects.
    Jenkins, J
    Nicholl, R
    Williams, D
    Baidoo, C
    Phillips, J
    Deng, YL
    Kitchen, V
    Erickson-Miller, C
    BLOOD, 2004, 104 (11) : 797A - 797A
  • [4] Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist
    Erickson-Miller, Connie L.
    Delorme, Evelyne
    Tian, Shin-Shay
    Hopson, Christopher B.
    Landis, Amy J.
    Valoret, Elizabeth I.
    Sellers, Teresa S.
    Rosen, Jon
    Miller, Stephen G.
    Luengo, Juan I.
    Duffy, Kevin J.
    Jenkins, Julian M.
    STEM CELLS, 2009, 27 (02) : 424 - 430
  • [5] Discovery of SB-497115, a small-molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia.
    Luengo, JI
    Duffy, KJ
    Shaw, AN
    Delorme, E
    Wiggall, KJ
    Giampa, L
    Liu, N
    Smith, H
    Tian, SS
    Miller, SG
    Keenan, RM
    Rosen, J
    Dillon, SB
    Lamb, P
    Erickson-Miller, CL
    BLOOD, 2004, 104 (11) : 795A - 795A
  • [6] Species specificity and receptor domain interaction of a small molecule Tpo receptor agonist, SB-497115
    Erickson-Miller, C
    Tian, S
    Hopson, C
    Luengo, J
    Uhl, J
    Rosen, J
    Sellers, T
    TRANSFUSION, 2005, 45 (03) : 43A - 43A
  • [7] Single and multiple oral doses of LGD-4665, a small molecule thrombopoietin receptor agonist, increase platelet counts in healthy male subjects
    Dziewanowska, Zofia E.
    Matsumoto, Richard M.
    Zhang, J. K.
    Schindler, Kristine
    Loewen, Gordon
    Doherty, James P.
    Berg, Jolene K.
    Newberry, Barbara
    BLOOD, 2007, 110 (11) : 390A - 390A
  • [8] In vitro biological activity of SB-497115, an orally bioavailable, small molecule platelet growth factor
    Erickson-Miller, C.
    Delorme, E.
    Tian, S.-S.
    Hopson, C.
    Valoret, E.
    Uhl, J.
    Rosen, J.
    Duffy, K.
    Luengo, J.
    EJC SUPPLEMENTS, 2005, 3 (02): : 49 - 49
  • [9] SINGLE AND MULTIPLE ORAL DOSES OF LGD-4665, A SMALL MOLECULE THROMBOPOIETIN RECEPTOR AGONIST, INCREASE PLATELET COUNTS IN HEALTHY MALE SUBJECTS AND DEMONSTRATE POTENTIAL TO TREAT THROMBOCYTOPENIC PATIENTS
    Dziewanowska, E.
    Zhang, J.
    Kapil, P.
    Greenberg, G.
    Matsumoto, M.
    Schindler, J.
    Berg, J.
    Newberry, B.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 377 - 378
  • [10] Discovery of eltrombopag (Promacta®), a novel small-molecule, oral thrombopoietin receptor agonist
    Luengo, Juan I.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238