SB-497115, a novel, oral, small molecule thrombopoietin receptor agonist, increases platelet counts in healthy subjects

被引：0
|
作者：
Jenkins, JM
Williams, D
Collins, DA
Deng, Y
Kitchen, V
Erickson-Miller, C
机构：
[1] GlaxoSmithKline R&D, Collegeville, PA USA
[2] GlaxoSmithKline R&D, Res Triangle Pk, NC USA
来源：
EXPERIMENTAL HEMATOLOGY | 2005年 / 33卷 / 07期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
105
引用
收藏
页码：64 / 65
页数：2
相关论文
共 44 条
  • [21] The non-peptide thrombopoietin receptor agonist Eltrombopag (SB-497115, Promacta/Revolade) does not stimulate malignant growth of bone marrow cells from patients with acute myeloid leukemia or myelodysplastic syndromes
    Will, B.
    Luciano, J.
    Kawahara, M.
    Erickson-Miller, C.
    Verma, A.
    Aivado, M.
    Steidl, U.
    LEUKEMIA RESEARCH, 2009, 33 : S46 - S47
  • [22] Safety, tolerability, pharmacokinetics, and pharmacodynamics of a novel oral small molecule GLP-1 receptor agonist (HRS-7535) in healthy subjects
    Wu, J.
    Hu, W.
    Du, Y.
    Zhang, Q.
    Zhou, R.
    Zhang, Q.
    Qin, H.
    Ye, Z.
    Xu, Y.
    Feng, S.
    Shu, C.
    Shen, Y.
    Fan, Y.
    DIABETOLOGIA, 2023, 66 (SUPPL 1) : S316 - S317
  • [23] Stimulation of platelet production in healthy volunteers by a novel, pegylated, peptide-based thrombopoietin (TPO) receptor agonist
    Moolenaar, M.
    Cerneus, D.
    Brown, K.
    End, D.
    De Kam, M. L.
    Cohen, A. F.
    Burggraaf, J.
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 62 (06) : 728 - 729
  • [24] Stimulation of platelet production in healthy volunteers by a novel pegylated peptide-based thrombopoietin (TPO) receptor agonist.
    Cerneus, D
    Brown, K
    Harris, R
    End, D
    Molloy, C
    Yurkow, E
    Koblish, H
    Franks, C
    Moolenaar, M
    Burggraaf, K
    BLOOD, 2005, 106 (11) : 363A - 364A
  • [25] Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Of Amg 986, a Novel Small Molecule Apelin Receptor Agonist, in Healthy Subjects and Heart Failure Patients
    Hellawell, Jennifer
    Abbasi, Siddique
    Trivedi, Ashit
    Tsirtsonis, Kate
    Kaufman, Allegra
    JOURNAL OF CARDIAC FAILURE, 2020, 26 (10) : S68 - S68
  • [26] Clinical Characterization of a Novel Oral Thrombopoietin Mimetic LGD-4665 in Healthy Volunteers Demonstrate Safe and Sustained Increases in Platelet Counts with Flexible Dosing Choices for Phase II Trials
    Dziewanowska, Zofia E.
    Kapil, Ram P.
    Zhang, J. K.
    Berg, Jolene K.
    Stevens, Victor J.
    Matsumoto, Richard M.
    Greenberg, Lisa
    Morris, Maryanna Y.
    BLOOD, 2008, 112 (11) : 1168 - 1168
  • [27] A First-in-Human Study of RGT-075, a Novel, Orally Bioavailable, Small-Molecule GLP-1 Receptor Agonist, in Healthy Adult Subjects
    Pirner, Mark A.
    Lin, Jing
    Liu, Feng
    Yao, Lili
    Zettler, Marjorie E.
    Valacer, David J.
    DIABETES, 2022, 71
  • [28] Tolerability and Pharmacokinetics of Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor-γ Agonist, After a Single Oral Administration in Healthy Female Subjects
    Min Kyu Park
    Tae-Eun Kim
    JaeWoo Kim
    Chin Kim
    Seo Hyun Yoon
    Joo-Youn Cho
    In-Jin Jang
    Kyung-Sang Yu
    Kyoung Soo Lim
    Clinical Drug Investigation, 2014, 34 : 467 - 474
  • [29] PHARMACOKINETICS AND TOLERABILITY OF A NOVEL ORAL PROSTACYCLIN IP RECEPTOR AGONIST, ACT-293987 AFTER A SINGLE-DOSE ADMINISTRATION IN HEALTHY SUBJECTS
    Sidharta, Patricia N.
    Okubo, Kaori
    Mant, Tim
    Dingernanse, Jasper
    Mukai, Hideya
    JOURNAL OF CLINICAL PHARMACOLOGY, 2010, 50 (09): : 1070 - 1070
  • [30] Tolerability and Pharmacokinetics of Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor-γ Agonist, After a Single Oral Administration in Healthy Female Subjects
    Park, Min Kyu
    Kim, Tae-Eun
    Kim, JaeWoo
    Kim, Chin
    Yoon, Seo Hyun
    Cho, Joo-Youn
    Jang, In-Jin
    Yu, Kyung-Sang
    Lim, Kyoung Soo
    CLINICAL DRUG INVESTIGATION, 2014, 34 (07) : 467 - 474
12345