Discovery of eltrombopag (Promacta®), a novel small-molecule, oral thrombopoietin receptor agonist

被引：0
|
作者：
Luengo, Juan I. [1 ]
机构：
[1] GlaxoSmithKline Inc, Oncol R&D, Dept Chem, Collegeville, PA 19426 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 238卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
590-ORGN
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Eltrombopag: A Novel Oral Thrombopoietin Receptor Agonist
    Corman, Shelby L.
    Mohammad, Rima A.
    ANNALS OF PHARMACOTHERAPY, 2010, 44 (06) : 1072 - 1079
  • [2] Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function
    Erhardt, Joseph A.
    Erickson-Miller, Connie L.
    Aivado, Manuel
    Abboud, Melanie
    Pillarisetti, Kodandaram
    Toomey, John R.
    EXPERIMENTAL HEMATOLOGY, 2009, 37 (09) : 1030 - 1037
  • [3] Eltrombopag - an oral thrombopoietin agonist
    Sharma, V.
    Randhawa, H.
    Sharma, A.
    Aggarwal, S.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2012, 16 (06) : 743 - 746
  • [4] Eltrombopag: the discovery of a second generation thrombopoietin-receptor agonist
    Stasi, Roberto
    EXPERT OPINION ON DRUG DISCOVERY, 2009, 4 (01) : 85 - 93
  • [5] Discovery of SB-497115, a small-molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia.
    Luengo, JI
    Duffy, KJ
    Shaw, AN
    Delorme, E
    Wiggall, KJ
    Giampa, L
    Liu, N
    Smith, H
    Tian, SS
    Miller, SG
    Keenan, RM
    Rosen, J
    Dillon, SB
    Lamb, P
    Erickson-Miller, CL
    BLOOD, 2004, 104 (11) : 795A - 795A
  • [6] Eltrombopag: A Novel Oral Thrombopoietin Receptor Agonist (vol 44, pg 1072, 2010)
    Corman, Shelby L.
    ANNALS OF PHARMACOTHERAPY, 2010, 44 (7-8) : 1353 - 1353
  • [7] Eltrombopag: An Oral Thrombopoietin Receptor Agonist for the Treatment of Idiopathic Thrombocytopenic Purpura
    Zhang, Yang
    Kolesar, Jill M.
    CLINICAL THERAPEUTICS, 2011, 33 (11) : 1560 - 1576
  • [8] Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
    Jenkins, Julian M.
    Williams, Daphne
    Deng, Yanli
    Uhl, Joanne
    Kitchen, Valerie
    Collins, David
    Erickson-Miller, Connie L.
    BLOOD, 2007, 109 (11) : 4739 - 4741
  • [9] Discovery of a novel small molecule agonist scaffold for the APJ receptor
    Narayanan, Sanju
    Maitra, Rangan
    Deschamps, Jeffery R.
    Bortoff, Katherine
    Thomas, James B.
    Zhang, Yanyan
    Warner, Keith
    Vasukuttan, Vineetha
    Decker, Ann
    Runyon, Scott P.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (16) : 3758 - 3770
  • [10] Eltrombopag (Promacta), a Thrombopoetin Receptor Agonist for the Treatment of Thrombocytopenia: Current and Future Considerations
    Serebruany, Victor L.
    Eisert, Christian
    Sabaeva, Elena
    Makarov, Leonid
    AMERICAN JOURNAL OF THERAPEUTICS, 2010, 17 (01) : 68 - 74
12345