Rare complication of hepatocellular carcinoma in Wilson's disease

被引：7
|
作者：
Ohkoshi-Yamada, Marina [1 ]
Kamimura, Kenya [1 ,2 ]
Kamimura, Hiroteru [1 ]
Terai, Shuji [1 ]
机构：
[1] Niigata Univ, Grad Sch Med & Dent Sci, Div Gastroenterol & Hepatol, Niigata, Japan
[2] Niigata Univ, Sch Med, Dept Gen Med, Niigata, Japan
来源：
JGH OPEN | 2021年 / 5卷 / 10期
关键词：
D-penicillamine; fatty infiltration; hepatocellular carcinoma; Wilson's disease;
D O I：
10.1002/jgh3.12648
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The complication of hepatocellular carcinoma (HCC) in Wilson's disease is rare. Wilson's disease treatment using D-penicillamine (DPA) is useful to prevent HCC occurrence; however, it also causes iron accumulation and synergistic radical formation in the liver, which may enhance carcinogenesis. Reported herein is a case of HCC in Wilson's disease treated with DPA for 36 years. The tumor was surgically resected and histologically diagnosed with moderately differentiated HCC surrounded by cirrhotic tissue with fatty infiltration. Rhodanine staining revealed a slight positively stained area in both tumor and surrounding tissues. Information obtained from this case and literature review highlight the feature of HCC in Wilson's disease.
引用
收藏
页码：1220 / 1222
页数：3
相关论文
共 50 条
  • [1] Hepatocellular carcinoma in Wilson's disease: A rare association in childhood
    Savas, Nurten
    Canan, Oguz
    Ozcay, Figen
    Bilezikci, Banu
    Karakayali, Hamdi
    Yilmaz, Ugur
    Haberal, Mehmet
    [J]. PEDIATRIC TRANSPLANTATION, 2006, 10 (05) : 639 - 643
  • [2] Hepatocellular carcinoma associated with Wilson's disease
    Savas, N.
    Canan, O.
    Ozcay, F.
    Yilmaz, U.
    Emiroglu, R.
    Haberal, M.
    [J]. LIVER INTERNATIONAL, 2006, 26 : 69 - 70
  • [3] Hepatocellular carcinoma in a case of Wilson's disease
    Hamid, Noufkhalid
    Zakary, Nawaf
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2013, 28 : 158 - 158
  • [4] Hepatocellular carcinoma associated with Wilson's disease
    Iwadate, H
    Ohira, H
    Suzuki, T
    Abe, K
    Yokokawa, J
    Takiguchi, J
    Rai, T
    Orikasa, H
    Irisawa, A
    Obara, K
    Kasukawa, R
    Sato, Y
    [J]. INTERNAL MEDICINE, 2004, 43 (11) : 1042 - 1045
  • [5] It's Raining Clots: Hemobilia a Rare Complication of Hepatocellular Carcinoma
    Patel, Adwait
    Sondhi, Neil
    Hoskere, Dhanush
    Hsieh, Jennifer
    Dedousis, John
    Tsompanidis, Antonio
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2023, 118 (10): : S2312 - S2312
  • [6] Small hepatocellular carcinoma associated with Wilson's disease
    Kumagi, T
    Horiike, N
    Abe, M
    Kurose, K
    Iuchi, H
    Masumoto, T
    Joko, K
    Akbar, F
    Michitaka, K
    Onji, M
    [J]. INTERNAL MEDICINE, 2005, 44 (05) : 439 - 443
  • [7] Wilson disease and hepatocellular carcinoma
    Harada, M
    [J]. INTERNAL MEDICINE, 2004, 43 (11) : 1012 - 1013
  • [8] Renal Cell Carcinoma and Hepatocellular Carcinoma in a Patient with Wilson's Disease
    Kitahata, Shogo
    Michitaka, Kojiro
    Kinebuchi, Miyuki
    Matsuura, Akihiro
    Hiraoka, Atsushi
    Ohama, Hideko
    Yanagihara, Emi
    Saneto, Hironobu
    Izumoto, Hirofumi
    Kawamura, Tomoe
    Kuroda, Taira
    Tada, Fujimasa
    Miyata, Hideki
    Ninomiya, Tomoyuki
    Hiasa, Yoichi
    [J]. INTERNAL MEDICINE, 2024, 63 (07) : 963 - 968
  • [9] Hepatocellular carcinoma associated with an atypical presentation of Wilson's disease
    Xu, Ruliang
    Bu-Ghanim, Moueen
    Fiel, M. Isabel
    Schiano, Thomas
    Cohen, Emil
    Thung, Swan N.
    [J]. SEMINARS IN LIVER DISEASE, 2007, 27 (01) : 122 - 127
  • [10] HEPATOCELLULAR CARCINOMA RUPTURE: A RARE COMPLICATION OF HCC
    de Choudens, Fabiola Rios
    [J]. JOURNAL OF GENERAL INTERNAL MEDICINE, 2017, 32 : S508 - S509
12345