Rare complication of hepatocellular carcinoma in Wilson's disease

被引：7
|
作者：
Ohkoshi-Yamada, Marina [1 ]
Kamimura, Kenya [1 ,2 ]
Kamimura, Hiroteru [1 ]
Terai, Shuji [1 ]
机构：
[1] Niigata Univ, Grad Sch Med & Dent Sci, Div Gastroenterol & Hepatol, Niigata, Japan
[2] Niigata Univ, Sch Med, Dept Gen Med, Niigata, Japan
来源：
JGH OPEN | 2021年 / 5卷 / 10期
关键词：
D-penicillamine; fatty infiltration; hepatocellular carcinoma; Wilson's disease;
D O I：
10.1002/jgh3.12648
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The complication of hepatocellular carcinoma (HCC) in Wilson's disease is rare. Wilson's disease treatment using D-penicillamine (DPA) is useful to prevent HCC occurrence; however, it also causes iron accumulation and synergistic radical formation in the liver, which may enhance carcinogenesis. Reported herein is a case of HCC in Wilson's disease treated with DPA for 36 years. The tumor was surgically resected and histologically diagnosed with moderately differentiated HCC surrounded by cirrhotic tissue with fatty infiltration. Rhodanine staining revealed a slight positively stained area in both tumor and surrounding tissues. Information obtained from this case and literature review highlight the feature of HCC in Wilson's disease.
引用
收藏
页码：1220 / 1222
页数：3
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