Small hepatocellular carcinoma associated with Wilson's disease

被引：23

作者：

Kumagi, T ^{[1
]}

Horiike, N ^{[1
]}

Abe, M ^{[1
]}

Kurose, K ^{[1
]}

Iuchi, H ^{[1
]}

Masumoto, T ^{[1
]}

Joko, K ^{[1
]}

Akbar, F ^{[1
]}

Michitaka, K ^{[1
]}

Onji, M ^{[1
]}

机构：

[1] Ehime Univ, Sch Med, Dept Internal Med 3, Toon, Ehime 7910295, Japan

来源：

INTERNAL MEDICINE | 2005年 / 44卷 / 05期

关键词：

Wilson's disease; hepatocellular carcinoma; chemoembolization; hepatic failure;

D O I：

10.2169/internalmedicine.44.439

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a 66-year-old male patient with hepatocellular carcinoma (HCC) associated with Wilson's disease. The patient presented with unresolving abnormal liver function test, decreased serum ceruloplasmin levels and increased 24-hour urine copper excretion. Liver biopsy specimen revealed the presence of increased levels of copper and features suggestive of Wilson's disease. Abdominal imaging showed the existence of a small HCC. Three years after chemoembolization and microwave coagulation therapy for HCC, he died of hepatic failure, which apparently resulted from chemoembolization. Patients with Wilson's disease should be screened for HCC. We should elude therapies such as chemoembolization in these patients.

引用

页码：439 / 443

页数：5

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