Isolation of 3,4-seco-27-norlanostane triterpenoids from cultivated fruiting bodies of Ganoderma orbiforme

被引：9
|
作者：
Li, Wei [1 ]
Chinthanom, Panida [2 ]
Rachtawee, Pranee [2 ]
Intereya, Kamoiphan [2 ]
Peng, Tao [1 ]
Liu, Ji-Kai [1 ]
Isaka, Masahiko [2 ]
机构：
[1] South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
[2] Natl Ctr Genet Engn & Biotechnol BIOTEC, 113 Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathumthani, Thailand
来源：
PHYTOCHEMISTRY LETTERS | 2018年 / 28卷
基金：
中国国家自然科学基金;
关键词：
Ganoderma orbiforme; Ganodermataceae; Lanostane triterpenes; Antibacterial activity; INHIBITORY-ACTIVITY; LANOSTANOIDS; METABOLITES; BONINENSE; REDUCTASE; LUCIDUM; ACIDS;
D O I：
10.1016/j.phytol.2018.09.017
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new 3,4-seco-27-norlanostane triterpenoids, ganoboninketals E (1) and F (2), and ganoboninones G (3) and H (4), and two known derivatives (5 and 6), a new C-30 lanostane, (24Z)-3 beta,27-dihydroxylanosta-7,9(11),24-triene (7), and twelve known lanostanes (8-19), together with three known meroterpenoids, fornicin A (20) and ganomycins B (21) and I (22), were isolated from cultivated fruiting bodies of the basidiomycete Ganoderma orbiforme. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data and chemical correlations. Biological activities of all new compounds and some selected known compounds were evaluated. Ganomycin I showed moderate activity against Gram-positive bacteria.
引用
收藏
页码：104 / 109
页数：6
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