The Brazilian version of the Quality of Life Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA) - Four-stage translation and validation

被引:3
|
作者
Ribeiro-Oliveira, Antonio, Jr. [1 ]
Mol, Suelem Simao [1 ]
Twiss, James [2 ]
Alencar, Guilherme Asmar [1 ]
Carvalho Miranda, Paulo Augusto
Naves, Luciana A. [3 ]
Azevedo, Monalisa F. [3 ]
Basilio, Flavia M. A. [4 ]
Boguszewski, Cesar Luiz [4 ]
Nogueira, Katia C. [5 ]
Vilar, Lucio [6 ]
Koltowska-Haggstrom, Maria [7 ]
McKenna, Steve P. [2 ]
机构
[1] Univ Fed Minas Gerais UFMG, Belo Horizonte, MG, Brazil
[2] Galen Res Ltd, Manchester, Lancs, England
[3] Univ Brasilia UnB, Brasilia, DF, Brazil
[4] Univ Fed Parana, Serv Endocrinol & Metabol SEMPR, BR-80060000 Curitiba, Parana, Brazil
[5] Hosp Brigadeiro, Sao Paulo, Brazil
[6] Univ Fed Pernambuco UFPE, Recife, PE, Brazil
[7] Pfizer Endocrine Care, KIMS Med Outcomes, Sollentuna, Sweden
关键词
Growth hormone; quality of life; treatment outcomes; QoL-AGHDA; GH REPLACEMENT THERAPY; PATIENT-REPORTED OUTCOMES; HYPOPITUITARY ADULTS; BODY-COMPOSITION; HEALTH; DENSITY; SWEDEN;
D O I
10.1590/S0004-27302010000900010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: This study reports on the Brazilian Portuguese adaptation of the QoL-AGHDA (Quality of Life Assessment of Growth Hormone Deficiency in Adults) for use in adult growth hormone deficient (GHD) patients. Materials and methods: The translation process adopted the dual panel methodology. The questionnaire was tested through field-test interviews (16 GHD patients). In the final stage, data from 120 GHD patients (81 included in a test-retest analysis) were analyzed for internal consistency, test-retest reliability, convergent validity and validity among known groups. Results: The translation panels were successful and the draft version was amended to improve the wording as a result of the field-test interviews. Cronbach's alpha was 0.90 and test-retest reliability 0.88. QoL-AGHDA scores had the expected pattern of association with NHP scale scores and QoL-AGHDA was able to differentiate significantly between patients based on patient-reported general health (p < 0.01) and QoL (p < 0.01). Conclusions:The adaptation of the QoL-AGHDA for a Brazilian population was successful and the adapted questionnaire was shown to be reliable and valid. Arq Bras Endocrine! Metab. 2010;54(9):833-41
引用
收藏
页码:833 / 841
页数:9
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