Primate Organoids and Gene-Editing Technologies toward Next-Generation Biomedical Research

被引：15

作者：

Chen, Chuanxin ^{[1
]}

Ji, Weizhi ^{[1
]}

Niu, Yuyu ^{[1
,2
]}

机构：

[1] Kunming Univ Sci & Technol, Inst Primate Translat Med, State Key Lab Primate Biomed Res, Kunming, Yunnan, Peoples R China

[2] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China

来源：

TRENDS IN BIOTECHNOLOGY | 2021年 / 39卷 / 12期

关键词：

HUMAN INTESTINAL ORGANOIDS; BLASTOCYST-LIKE STRUCTURES; PLURIPOTENT STEM-CELLS; CYNOMOLGUS MONKEY; DISEASE; MODEL; DERIVATION; DIVERSITY; CULTURE; REVEAL;

D O I：

10.1016/j.tibtech.2021.03.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The improved ability to organize pluripotent stem cells (PSCs) into 3D structures in vitro has shed light on organoid technology to recapitulate organs and tumors in vivo. Advances in gene-editing technologies, particularly CRISPR-mediated techniques, offer tremendous potential in facilitating organoid research, including the study of development, disease modeling, and personalized medicine. This review discusses how the combination of two novel technologies - organoids and gene editing - not only contributes to revealing molecular events taking place during development and tumorigenesis but also has implications for biobanking, precision medicine, and other diverse biomedical applications.

引用

页码：1332 / 1342

页数：11

共 50 条

[31] Risk-appropriate regulations for gene-editing technologies
Brookes, Graham
Smyth, Stuart J.
GM CROPS & FOOD-BIOTECHNOLOGY IN AGRICULTURE AND THE FOOD CHAIN, 2024, 15 (01): : 1 - 14
[32] Application of gene-editing technologies to HIV-1
Drake, Mary Jane
Bates, Paul
CURRENT OPINION IN HIV AND AIDS, 2015, 10 (02) : 123 - 127
[33] Next-Generation Sequencing Technologies
McCombie, W. Richard
McPherson, John D.
Mardis, Elaine R.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019, 9 (11):
[34] Next-generation technologies in the USA
McConnell, R
SEMICONDUCTORS, 2004, 38 (08) : 931 - 935
[35] Next-generation technologies in the USA
R. McConnell
Semiconductors, 2004, 38 : 931 - 935
[36] Next-generation CDMA technologies
Chen, HH
Vinck, AJH
Bi, Q
Adachi, F
Milstein, LB
IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS, 2006, 24 (01) : 1 - 3
[37] Bioengineering tools for next-generation neural organoids
O'Laughlin, Richard
Cheng, Fangyi
Song, Hongjun
Ming, Guo-li
CURRENT OPINION IN NEUROBIOLOGY, 2025, 92
[38] Next-Generation Modeling of Cancer Using Organoids
Love, Jillian R.
Karthaus, Wouter R.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2024, 14 (06):
[39] Germline gene-editing research needs rules
Nature, 2019, 567 (7747) : 145 - 145
[40] CRISPR Keeps Things Fresh: Next-Generation Tools for Gene Editing
Flotte, Terence R.
HUMAN GENE THERAPY, 2021, 32 (5-6) : 235 - 236

← 1 2 3 4 5 →