Primate Organoids and Gene-Editing Technologies toward Next-Generation Biomedical Research

被引：15

作者：

Chen, Chuanxin ^{[1
]}

Ji, Weizhi ^{[1
]}

Niu, Yuyu ^{[1
,2
]}

机构：

[1] Kunming Univ Sci & Technol, Inst Primate Translat Med, State Key Lab Primate Biomed Res, Kunming, Yunnan, Peoples R China

[2] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China

来源：

TRENDS IN BIOTECHNOLOGY | 2021年 / 39卷 / 12期

关键词：

HUMAN INTESTINAL ORGANOIDS; BLASTOCYST-LIKE STRUCTURES; PLURIPOTENT STEM-CELLS; CYNOMOLGUS MONKEY; DISEASE; MODEL; DERIVATION; DIVERSITY; CULTURE; REVEAL;

D O I：

10.1016/j.tibtech.2021.03.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The improved ability to organize pluripotent stem cells (PSCs) into 3D structures in vitro has shed light on organoid technology to recapitulate organs and tumors in vivo. Advances in gene-editing technologies, particularly CRISPR-mediated techniques, offer tremendous potential in facilitating organoid research, including the study of development, disease modeling, and personalized medicine. This review discusses how the combination of two novel technologies - organoids and gene editing - not only contributes to revealing molecular events taking place during development and tumorigenesis but also has implications for biobanking, precision medicine, and other diverse biomedical applications.

引用

页码：1332 / 1342

页数：11

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