Cytotoxic prenylated flavones from the stem and root bark of Daphne giraldii

被引：22

作者：

Sun, Qian ^{[1
,2
]}

Wang, Di ^{[1
,2
]}

Li, Fei-Fei ^{[1
,2
,3
]}

Yao, Guo-Dong ^{[4
]}

Li, Xue ^{[5
]}

Li, Ling-Zhi ^{[1
,2
]}

Huang, Xiao-Xiao ^{[1
,2
]}

Song, Shao-Jiang ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

[3] Yangtze River Pharmaceut Grp Co Ltd, Taizhou 225300, Peoples R China

[4] Shenyang Pharmaceut Univ, China Japan Res Inst Med Pharmaceut Sci, Shenyang 110016, Peoples R China

[5] Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 16期

关键词：

Daphne giraldii; Flavone; Cytotoxicity; Apoptosis; CONSTITUENTS; MECHANISM;

D O I：

10.1016/j.bmcl.2016.07.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new prenylated flavones (1-3), along with three known analogues (4-6), were isolated from the stem and root bark of Daphne giraldii. Their structures were determined by comprehensive NMR and HRESIMS spectroscopic data analyses. The absolute configurations of compounds 2 and 3 were assigned by optical rotation comparison, CD and [Rh-2(OCOCF3)(4)]-induced CD spectral methods. The in vitro cytotoxicity experiments carried out involving five cancer cell lines (U251, A549, HepG2, MCF-7 and Bcap37) showed that 2 markedly inhibited the proliferation of all tested cells with IC50 values ranging from 4.26 to 20.82 mu M. The preliminary structure-activity relationships of these flavones are discussed. In addition, compound 2 was found to effectively induce apoptosis in HepG2 cells according to a flow cytometry analysis. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：3968 / 3972

页数：5

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