A New Prenylated Coumarin from Daphne oleoides and its Cytotoxic Activity

被引：0
|
作者：
Muhammad Younus Dar
Tabassum Ara
Seema Akbar
机构：
[1] Naseem Bagh Campus University of Kashmir,Drug Standardisation Research Unit, RRIUM
[2] National Institute of Technology,Department of Chemistry
来源：
Chemistry of Natural Compounds | 2019年 / 55卷
关键词：
prenylated coumarin; Thymelaeaceae; cell lines; cytotoxic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new prenylated coumarin, 7-(4′-methylpentoxy)-2H-1-benzopyran-2-one (1), together with two known coumarins (2, 3), was isolated from the ethyl acetate extract of Daphne oleoides (Thymelaeaceae). Their structures were elucidated on the basis of extensive spectroscopic analysis. The three compounds (1–3) were screened for preliminary cytotoxic activity using MTT assay on human breast cancer (HBL-100), lung cancer (A549), and cervical cancer (HeLa) cell lines, which revealed that the compounds possess in vitro cytotoxic activity with IC50 values ranging between 23.99–49.13 μg/mL.
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页码：5 / 7
页数：2
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