Exons, introns, and DNA thermodynamics

被引：29
|
作者：
Carlon, E
Malki, ML
Blossey, R
机构：
[1] Interdisciplinary Res Inst, IEMN, F-59652 Villeneuve Dascq, France
[2] Ecole Natl Super Phys Strasbourg, F-67412 Illkirch Graffenstaden, France
来源：
PHYSICAL REVIEW LETTERS | 2005年 / 94卷 / 17期
关键词：
D O I：
10.1103/PhysRevLett.94.178101
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
The genes of eukaryotes are characterized by protein coding fragments, the exons, interrupted by introns, i.e., stretches of DNA which do not carry useful information for protein synthesis. We have analyzed the melting behavior of randomly selected human cDNA sequences obtained from genomic DNA by removing all introns. A clear correspondence is observed between exons and melting domains. This finding may provide new insights into the physical mechanisms underlying the evolution of genes.
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页数：4
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