RNAi therapeutic strategies for acute respiratory distress syndrome

被引：19

作者：

Jagrosse, Melissa L. ^{[1
]}

Dean, David A. ^{[2
]}

Rahman, Arshad ^{[2
]}

Nilsson, Bradley L. ^{[1
]}

机构：

[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA

[2] Univ Rochester, Sch Med & Dent, Dept Pediat & Neonatol, Rochester, NY USA

来源：

TRANSLATIONAL RESEARCH | 2019年 / 214卷

基金：

美国国家卫生研究院;

关键词：

ACUTE LUNG INJURY; CELL-PENETRATING-PEPTIDE; METERED-DOSE INHALER; NF-KAPPA-B; SMALL INTERFERING RNA; POSITIVE-PRESSURE VENTILATION; EXTRACORPOREAL CO2 REMOVAL; CHRONIC ALCOHOL-ABUSE; IN-VIVO; SIRNA DELIVERY;

D O I：

10.1016/j.trsl.2019.07.011

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Acute respiratory distress syndrome (ARDS), replacing the clinical term acute lung injury, involves serious pathophysiological lung changes that arise from a variety of pulmonary and nonpulmonary injuries and currently has no pharmacological therapeutics. RNA interference (RNAi) has the potential to generate therapeutic effects that would increase patient survival rates from this condition. It is the purpose of this review to discuss potential targets in treating ARDS with RNAi strategies, as well as to outline the challenges of oligonucleotide delivery to the lung and tactics to circumvent these delivery barriers.

引用

页码：30 / 49

页数：20

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