RNAi therapeutic strategies for acute respiratory distress syndrome

被引：19
|
作者：
Jagrosse, Melissa L. [1 ]
Dean, David A. [2 ]
Rahman, Arshad [2 ]
Nilsson, Bradley L. [1 ]
机构：
[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA
[2] Univ Rochester, Sch Med & Dent, Dept Pediat & Neonatol, Rochester, NY USA
来源：
TRANSLATIONAL RESEARCH | 2019年 / 214卷
基金：
美国国家卫生研究院;
关键词：
ACUTE LUNG INJURY; CELL-PENETRATING-PEPTIDE; METERED-DOSE INHALER; NF-KAPPA-B; SMALL INTERFERING RNA; POSITIVE-PRESSURE VENTILATION; EXTRACORPOREAL CO2 REMOVAL; CHRONIC ALCOHOL-ABUSE; IN-VIVO; SIRNA DELIVERY;
D O I：
10.1016/j.trsl.2019.07.011
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Acute respiratory distress syndrome (ARDS), replacing the clinical term acute lung injury, involves serious pathophysiological lung changes that arise from a variety of pulmonary and nonpulmonary injuries and currently has no pharmacological therapeutics. RNA interference (RNAi) has the potential to generate therapeutic effects that would increase patient survival rates from this condition. It is the purpose of this review to discuss potential targets in treating ARDS with RNAi strategies, as well as to outline the challenges of oligonucleotide delivery to the lung and tactics to circumvent these delivery barriers.
引用
收藏
页码：30 / 49
页数：20
相关论文
共 50 条
  • [21] Lung Transplantation as a Therapeutic Option in Acute Respiratory Distress Syndrome
    Chang, Youjin
    Lee, Sang Oh
    Shim, Tae Sun
    Choi, Sae Hoon
    Kim, Hyung Ryul
    Kim, Yong-Hee
    Kim, Dong Kwan
    Do, Kyung-Hyun
    Choi, In-Cheol
    Hong, Sang-Bum
    Park, Seung-Il
    TRANSPLANTATION, 2018, 102 (05) : 829 - 837
  • [22] NeuroWatch in acute respiratory distress syndrome: time to tune strategies
    Caldas, Juliana
    Passos, Rogerio da Hora
    INTENSIVE CARE MEDICINE, 2024, 50 (10) : 1725 - 1726
  • [23] Strategies against refractory hypoxemia in acute respiratory distress syndrome
    Martin, M. Delgado
    Fernandez Fernandez, R.
    MEDICINA INTENSIVA, 2013, 37 (06) : 423 - 430
  • [24] Mechanical ventilation and pharmacologic strategies for acute respiratory distress syndrome
    Cawley, MJ
    Skaar, DJ
    Anderson, HL
    Hanson, CW
    PHARMACOTHERAPY, 1998, 18 (01): : 140 - 155
  • [25] Acute respiratory distress syndrome Pathophysiology, definition and treatment strategies
    Staudinger, Thomas
    MEDIZINISCHE KLINIK-INTENSIVMEDIZIN UND NOTFALLMEDIZIN, 2025, 120 (01) : 81 - 93
  • [26] Current strategies for the diagnosis and treatment of acute respiratory distress syndrome
    Altintas, Neriman Defne
    Iskit, Arzu Topeli
    TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX, 2009, 57 (02): : 228 - 236
  • [27] Ventilatory strategies and supportive care in acute respiratory distress syndrome
    Luks, Andrew M.
    INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2013, 7 : 8 - 17
  • [28] Acute respiratory distress syndrome: Physiology and new management strategies
    Weinacker, AB
    Vaszar, LT
    ANNUAL REVIEW OF MEDICINE, 2001, 52 : 221 - 237
  • [29] Respiratory drive in the acute respiratory distress syndrome: pathophysiology, monitoring, and therapeutic interventions
    Spinelli, Elena
    Mauri, Tommaso
    Beitler, Jeremy R.
    Pesenti, Antonio
    Brodie, Daniel
    INTENSIVE CARE MEDICINE, 2020, 46 (04) : 606 - 618
  • [30] Respiratory drive in the acute respiratory distress syndrome: pathophysiology, monitoring, and therapeutic interventions
    Elena Spinelli
    Tommaso Mauri
    Jeremy R. Beitler
    Antonio Pesenti
    Daniel Brodie
    Intensive Care Medicine, 2020, 46 : 606 - 618
12345