Extracts of Ganoderma lucidum attenuate lipid metabolism and modulate gut microbiota in high-fat diet fed rats

被引:48
|
作者
Hu, Rongkang
Guo, Weiling
Huang, Zirui
Li, Lu
Liu, Bin [2 ]
Lv, Xucong [1 ]
机构
[1] Fujian Agr & Forestry Univ, Natl Engn Res Ctr JUNCAO Technol, Fuzhou 350002, Fujian, Peoples R China
[2] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China
关键词
Ganoderma lucidum; Ethanol extracts; Lipid metabolism; Gut microbiota; Triterpenoids; PERFORMANCE LIQUID-CHROMATOGRAPHY; TRITERPENOIDS; ACID; TIME; POLYSACCHARIDES; IDENTIFICATION; PLASMA; EAST; ASIA;
D O I
10.1016/j.jff.2018.05.020
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
This study aimed to investigate the effects of 55% ethanol extracts from G. lucidum (GL55) on high-fat diet (HFD) induced hyperlipidaemia and gut microbiota modulation in rats. UPLC-QTOF MS-MS indicated that GL55 was enriched with triterpenoids. GL55 markedly alleviated the dyslipidemia in HFD fed rats through decreasing the levels of serum total triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), alanine transaminase (ALT), free fatty acids (FFA), fasting blood-glucose (FBG) and inhibiting hepatic steatosis. Furthermore, high throughput sequencing analysis revealed that GL55 supplementation altered the composition of gut microbiota, in particular increased the relative abundance of functionally relevant enterotypes, such as Alloprevotella, Ruminococcus and Prevotella, but decreased the proportion of Turicibacter and Clostridium XVIII compared with the HFD group. The Spearman's correlation analysis revealed that Alloprevotella, Ruminococcus and Prevotella were negatively correlated with serum lipid profiles. Meanwhile, GL55 treatment regulated mRNA and protein expressions levels involved in lipid and glucose metabolism.
引用
收藏
页码:403 / 412
页数:10
相关论文
共 50 条
  • [41] ENHANCING EFFECT OF CAPSAICIN ON LIPID-METABOLISM IN RATS FED A HIGH-FAT DIET
    IWAI, K
    KAWADA, T
    WATANABE, T
    JOURNAL OF NUTRITION, 1986, 116 (06): : R28 - R28
  • [42] Theabrownin from Wuniuzao Dark Tea Regulates Hepatic Lipid Metabolism and Gut Microbiota in Mice Fed High-Fat Diet
    Xu, Qianqian
    Ye, Jiangcheng
    Gong, Mingxiu
    Zhang, Yifan
    Yuan, Yiwei
    Zhao, Jin
    NUTRIENTS, 2023, 15 (23)
  • [43] ENHANCING EFFECT OF CAPSAICIN ON LIPID-METABOLISM IN RATS FED A HIGH-FAT DIET
    IWAI, K
    KAWADA, T
    WATANABE, T
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 1986, 43 (06): : 47 - 47
  • [44] Astaxanthin from Haematococcus pluvialis alleviates obesity by modulating lipid metabolism and gut microbiota in mice fed a high-fat diet
    Wang, Meng
    Ma, Haotian
    Guan, Siyu
    Luo, Tao
    Zhao, Chunchao
    Cai, Guiping
    Zheng, Yubin
    Jia, Xiaoyun
    Di, Jianbing
    Li, Runzhi
    Cui, Hongli
    FOOD & FUNCTION, 2021, 12 (20) : 9719 - 9738
  • [45] A high-fat diet and high-fat and high-cholesterol diet may affect glucose and lipid metabolism differentially through gut microbiota in mice
    Liang, Huijing
    Jiang, Fengling
    Cheng, Ruyue
    Luo, Yating
    Wang, Jiani
    Luo, Zihao
    Li, Ming
    Shen, Xi
    He, Fang
    EXPERIMENTAL ANIMALS, 2021, 70 (01) : 73 - 83
  • [46] Walnut Meal Extracts Rich In Polyphenols Mitigate Insulin Resistance and Modulate Gut Microbiota in High Fat Diet-Fed Rats
    He, Xingping
    Chen, Dan
    Guo, Yan
    Zhang, Xi
    Ma, Yage
    Zhao, Shenglan
    JOURNAL OF MEDICINAL FOOD, 2022, 25 (06) : 618 - 629
  • [47] Ganoderma polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition in high fat diet-fed golden hamsters
    Tong, Ai-Jun
    Hu, Rong-Kang
    Wu, Lin-Xiu
    Lv, Xu-Cong
    Li, Xin
    Zhao, Li-Na
    Liu, Bin
    JOURNAL OF FOOD BIOCHEMISTRY, 2020, 44 (01)
  • [48] Polyphenol-Rich Extracts from Brown Macroalgae Lessonia trabeculate Attenuate Hyperglycemia and Modulate Gut Microbiota in High-Fat Diet and Streptozotocin-Induced Diabetic Rats
    Yuan, Yuan
    Zheng, Yanfen
    Zhou, Jinhui
    Geng, Yuting
    Zou, Ping
    Li, Yiqiang
    Zhang, Chengsheng
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 67 (45) : 12472 - 12480
  • [49] Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high-fat diet-fed mice
    Yin, Jie
    Li, Yuying
    Han, Hui
    Chen, Shuai
    Gao, Jing
    Liu, Gang
    Wu, Xin
    Deng, Jinping
    Yu, Qifang
    Huang, Xingguo
    Fang, Rejun
    Li, Tiejun
    Reiter, Russel J.
    Zhang, Dong
    Zhu, Congrui
    Zhu, Guoqiang
    Ren, Wenkai
    Yin, Yulong
    JOURNAL OF PINEAL RESEARCH, 2018, 65 (04)
  • [50] Depletion of Gut Microbiota Inhibits Hepatic Lipid Accumulation in High-Fat Diet-Fed Mice
    Han, Hui
    Wang, Mengyu
    Zhong, Ruqing
    Yi, Bao
    Schroyen, Martine
    Zhang, Hongfu
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (16)