Extracts of Ganoderma lucidum attenuate lipid metabolism and modulate gut microbiota in high-fat diet fed rats

被引:48
|
作者
Hu, Rongkang
Guo, Weiling
Huang, Zirui
Li, Lu
Liu, Bin [2 ]
Lv, Xucong [1 ]
机构
[1] Fujian Agr & Forestry Univ, Natl Engn Res Ctr JUNCAO Technol, Fuzhou 350002, Fujian, Peoples R China
[2] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China
关键词
Ganoderma lucidum; Ethanol extracts; Lipid metabolism; Gut microbiota; Triterpenoids; PERFORMANCE LIQUID-CHROMATOGRAPHY; TRITERPENOIDS; ACID; TIME; POLYSACCHARIDES; IDENTIFICATION; PLASMA; EAST; ASIA;
D O I
10.1016/j.jff.2018.05.020
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
This study aimed to investigate the effects of 55% ethanol extracts from G. lucidum (GL55) on high-fat diet (HFD) induced hyperlipidaemia and gut microbiota modulation in rats. UPLC-QTOF MS-MS indicated that GL55 was enriched with triterpenoids. GL55 markedly alleviated the dyslipidemia in HFD fed rats through decreasing the levels of serum total triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), alanine transaminase (ALT), free fatty acids (FFA), fasting blood-glucose (FBG) and inhibiting hepatic steatosis. Furthermore, high throughput sequencing analysis revealed that GL55 supplementation altered the composition of gut microbiota, in particular increased the relative abundance of functionally relevant enterotypes, such as Alloprevotella, Ruminococcus and Prevotella, but decreased the proportion of Turicibacter and Clostridium XVIII compared with the HFD group. The Spearman's correlation analysis revealed that Alloprevotella, Ruminococcus and Prevotella were negatively correlated with serum lipid profiles. Meanwhile, GL55 treatment regulated mRNA and protein expressions levels involved in lipid and glucose metabolism.
引用
收藏
页码:403 / 412
页数:10
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