Registration of 3D FMT and CT images of mouse via affine transformation using Sequential Monte Carlo

It is difficult to directly co-register the 3D FMT (Fluorescence Molecular Tomography) image of a small tumor in a mouse whose maximal diameter is only a few turn with a larger CT image of the entire animal that spans about ten cm. This paper proposes a new method to register 2D flat and 3D CT image first to facilitate the registration between small 3D FMT images and large CT images. A novel algorithm based on SMC (Sequential Monte Carlo) incorporated with least square operation for the registration between the 2D flat and 3D CT images is introduced and validated with simulated images and real images of mice. The visualization of the preliminary alignment of the 3D FMT and CT image through 2D registration shows promising results.