Inhibition of 2-oxoglutarate dehydrogenase complex by free fatty acids

被引：0
|
作者：
Ostrovtsova, SA
机构：
来源：
MEDICAL SCIENCE RESEARCH | 1996年 / 24卷 / 09期
关键词：
oxoglutarate dehydrogenase complex; heart; fatty acids; Krebs cycle;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Fatty acids, along with carbohydrates, are the main sources of fuel for the Krebs cycle in the form of acetyl-CoA. They have a regulatory role in liver and heart. We studied the possibility of regulation of the activity of 2-oxoglutarate dehydrogenase complex (OGDC) and its first component, oxoglutarate dehydrogenase (OGD), in bovine heart by free long chain fatty acids. The results indicate that oleate plays a significant role in OGDC and OGD function by changing kinetic parameters of the complex. This fatty acid inhibits oxoglutarate dehydrogenase complex activity with 2-oxoglutarate by increasing [S](0.5) values.
引用
收藏
页码：625 / 627
页数：3
相关论文
共 50 条
  • [31] THE 2-OXOGLUTARATE DEHYDROGENASE COMPLEX FROM AZOTOBACTER-VINELANDII .1. MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF THE GENE ENCODING THE 2-OXOGLUTARATE DEHYDROGENASE COMPONENT
    SCHULZE, E
    WESTPHAL, AH
    HANEMAAIJER, R
    DEKOK, A
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 187 (01): : 229 - 234
  • [32] Modulation of 2-oxoglutarate dehydrogenase by Pi and other effectors
    Rodríguez-Zavala, JS
    Pardo, JP
    Moreno-Sánchez, R
    BIOPHYSICAL JOURNAL, 1999, 76 (01) : A179 - A179
  • [33] DIFFERENCES IN 2-OXOGLUTARATE DEHYDROGENASE REGULATION IN LIVER AND KIDNEY
    MCCORMACK, JG
    BIOCHEMICAL JOURNAL, 1993, 295 : 899 - 900
  • [34] DIFFERENCES IN 2-OXOGLUTARATE DEHYDROGENASE REGULATION IN LIVER AND KIDNEY
    SMITH, BC
    CLOTFELTER, LA
    CHEUNG, JY
    LANOUE, KF
    BIOCHEMICAL JOURNAL, 1992, 284 : 819 - 826
  • [35] Modeling the Kinetics and Regulation of Mammalian 2-Oxoglutarate Dehydrogenase
    Qi, Feng
    Pradhan, Ranjan K.
    Dash, Ranjan K.
    Beard, Daniel A.
    FASEB JOURNAL, 2011, 25
  • [36] Detailed kinetics and regulation of mammalian 2-oxoglutarate dehydrogenase
    Qi, Feng
    Pradhan, Ranjan K.
    Dash, Ranjan K.
    Beard, Daniel A.
    BMC BIOCHEMISTRY, 2011, 12
  • [37] SUBUNIT COMPOSITION AND PARTIAL REACTIONS OF THE 2-OXOGLUTARATE DEHYDROGENASE COMPLEX OF ACETOBACTER-XYLINUM
    DEKOK, A
    KORNFELD, S
    BENZIMAN, M
    MILNER, Y
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1980, 106 (01): : 49 - 58
  • [38] SOME REGULATORY PROPERTIES OF THE 2-OXOGLUTARATE DEHYDROGENASE COMPLEX FROM EUROPEAN BISON HEART
    MARKIEWICZ, J
    STRUMILO, SA
    ACTA BIOCHIMICA POLONICA, 1995, 42 (03) : 339 - 346
  • [39] Cellular localization of the hybrid pyruvate/2-oxoglutarate dehydrogenase complex in the actinobacterium Corynebacterium glutamicum
    Sundermeyer, Lea
    Folkerts, Jan-Gerrit
    Lueckel, Benita
    Mack, Christina
    Baumgart, Meike
    Bott, Michael
    MICROBIOLOGY SPECTRUM, 2023, 11 (05):
  • [40] DOOR syndrome: Deficiency of E1 component of the 2-oxoglutarate dehydrogenase complex
    Surendran, S
    Michals-Matalon, K
    Krywawych, S
    Qazi, QH
    Tuchman, R
    Rady, PL
    Tyring, SK
    Matalon, R
    AMERICAN JOURNAL OF MEDICAL GENETICS, 2002, 113 (04): : 371 - 374
12345