Facile synthetic route to selectively protected spermidine homologues

被引：3

作者：

Andruszkiewicz, Ryszard ^{[1
]}

Gronek, Ewa ^{[1
]}

Haluszczak, Jolanta ^{[1
]}

机构：

[1] Gdansk Univ Technol, Dept Pharmaceut Technol & Biochem, Gdansk, Poland

来源：

SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 06期

关键词：

Hofmann degradation; Michael addition; polyamines; protecting groups;

D O I：

10.1080/00397910701845431

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several selectively protected spermidine homologues were synthesized via cyanoethylation reaction of monoprotected diamines, subsequent protection of their secondary amino group, hydrolysis of nitrile to primary amide function, and final Hofmann degradation of amides to amines with the aid of iodosobenzene diacetate (PIDA). The protected spermidine homologues may be directly used in the synthesis of polyamine amides or may be further functionalized.

引用

页码：905 / 913

页数：9

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