Nonaqueous capillary electrophoretic chiral separations of anticholinergic drugs with heptakis(2,3-di-O-methyl-6-O-Sulfato)-cyclodextrin

被引：1

作者：

Du, GH ^{[1
]}

Qin, L ^{[1
]}

Xie, JW ^{[1
]}

Yun, LH ^{[1
]}

Zhong, BH ^{[1
]}

Liu, KL ^{[1
]}

机构：

[1] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

来源：

CHROMATOGRAPHIA | 2005年 / 61卷 / 9-10期

关键词：

nonaqueous capillary electrophoresis; methanol background electrolyte; enantiomer separations; heptakis(2,3-di-O-methyl-O-sulfato)-beta-cyclodextrin; anticholinergic drugs;

D O I：

10.1365/s10337-005-0540-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper reports the use of an anionic cyclodextrin, heptakis(2,3-di-O-methyl-6-O-sulfato)-beta-cycloclextrin (HDMS-beta-CD), for chiral separations of pharmaceutical enantiomers by nonaqueous capillary electrophoresis (NACE). Enantiomer resolution was affected mainly by HDMS-beta-CD concentration and the acidity of the background electrolyte (BGE). The effects of capillary length and applied voltage on enantiomer resolution were also investigated. Results showed that in a methanol solution of 20 mM phosphoric acid, 10 mM sodium hydroxide, and 10 mM HDMS-P-CD, seven anticholinergic drugs were separated to baseline but no chiral separation was obtained for three other similar drugs. NACE is suitable for routine, rapid separation of the enantiomers of pharmaceutical compounds.

引用

页码：527 / 531

页数：5

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