Synthesis of novel spiro(indolizine-pyrazole) derivatives via 1,3-dipolar cycloaddition of nitrilimine

被引：6
|
作者：
Zhang, Shaowei [1 ]
Hu, Xiaolian [1 ]
Tao, Hongwen [1 ]
Liu, Haochong [1 ]
Li, Xiaofang [1 ]
机构：
[1] Hunan Univ Sci & Technol, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Sch Chem & Chem Engn, Xiangtan 411201, Hunan, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2017年 / 10期
基金：
中国国家自然科学基金;
关键词：
indolizine; spiroheterocycle; 1,3-dipolar cycloaddition; nitrilimine; BIOLOGICAL EVALUATION; INDOLIZIDINE; DESIGN; AGENTS;
D O I：
10.3184/174751917X15064232103100
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The 1,3-dipolar cycloaddition of nitrilimine, generated in situ from N'-phenylbenzohydrazonoyl chloride and triethylamine, to 7-arylmethylidene-6,7-dihydroindolizin-8(5H)-one afforded novel 4'-aryl-2', 5'-diphenyl-2', 4', 5,6-tetrahydro-8H-spiro(indolazine-7,3'-pyrazol)-8-ones in moderate yields. The structures of all the products were characterised thoroughly by NMR, infrared spectroscopy and HRMS. The structure and stereochemistry was confirmed by X-ray diffraction analysis.
引用
收藏
页码：608 / 610
页数：3
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