Quantifying Small Molecules by Mass Spectrometry

被引：0

作者：

Gale, P. Jane ^{[1
]}

Yergey, Alfred L.

Duncan, Mark W. ^{[2
,3
]}

Yu, Kate ^{[1
]}

机构：

[1] Waters Corp, Milford, MA 01757 USA

[2] Univ Colorado, Sch Med, Boulder, CO 80309 USA

[3] Biodesix Inc, Boulder, CO USA

来源：

LC GC EUROPE | 2014年 / 27卷 / 12期

关键词：

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The use of a mass spectrometer in quantitative analysis exploits its exquisite selectivity and sensitivity as a detector, allowing a signal to be ascribed to a particular chemical entity with high certainty, even when present in a sample at a low concentration. There are, however, some special considerations that are necessary when a mass spectrometer is used as a quantitative tool. In this instalment, we discuss the general precepts of quantitative analysis, as well as the concept of "fitness for purpose", in the context of those considerations.

引用

页码：653 / 658

页数：6

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