Quantifying Small Molecules by Mass Spectrometry

被引：0
|
作者：
Gale, P. Jane [1 ]
Yergey, Alfred L.
Duncan, Mark W. [2 ,3 ]
Yu, Kate [1 ]
机构：
[1] Waters Corp, Milford, MA 01757 USA
[2] Univ Colorado, Sch Med, Boulder, CO 80309 USA
[3] Biodesix Inc, Boulder, CO USA
来源：
LC GC EUROPE | 2014年 / 27卷 / 12期
关键词：
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The use of a mass spectrometer in quantitative analysis exploits its exquisite selectivity and sensitivity as a detector, allowing a signal to be ascribed to a particular chemical entity with high certainty, even when present in a sample at a low concentration. There are, however, some special considerations that are necessary when a mass spectrometer is used as a quantitative tool. In this instalment, we discuss the general precepts of quantitative analysis, as well as the concept of "fitness for purpose", in the context of those considerations.
引用
收藏
页码：653 / 658
页数：6
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