Synthesis and analgesic activity of new 1,3,4-oxadiazoles and 1,2,4-triazoles

被引：36

作者：

Almasirad, Ali ^{[1
]}

Shafiee, Abbas ^{[2
,3
]}

Abdollahi, Mohammad ^{[3
,4
]}

Noeparast, Amir ^{[3
,4
]}

Shahrokhinejad, Nasir ^{[3
,4
]}

Vousooghi, Nasim ^{[5
]}

Tabatabai, Sayyed Abbas ^{[6
]}

Khorasani, Reza ^{[3
,4
]}

机构：

[1] Islamic Azad Univ, Dept Med Chem, Pharmaceut Sci Branch, Tehran 1941933111, Iran

[2] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran 14174, Iran

[3] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran 14174, Iran

[4] Univ Tehran Med Sci, Dept Pharmacol & Toxicol, Fac Pharm, Tehran 14174, Iran

[5] Shahid Beheshti Univ Med Sci, Dept Pharmacol, Fac Med, Tehran, Iran

[6] Shahid Beheshti Univ Med Sci, Dept Med Chem, Sch Pharm, Tehran, Iran

来源：

MEDICINAL CHEMISTRY RESEARCH | 2011年 / 20卷 / 04期

基金：

美国国家科学基金会;

关键词：

1,3,4-Oxadiazole; 1,2,4-Triazole; Analgesic activity; Formalin test; DUAL INHIBITORS; FORMALIN TEST; ANTIINFLAMMATORY DRUGS; BIOLOGICAL EVALUATION; 1,3,4-THIADIAZOLE; CYCLOOXYGENASES; MANAGEMENT; MORPHINE; AGENTS; RATS;

D O I：

10.1007/s00044-010-9335-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new 1,3,4-oxadiazoles and 1,2,4-triazoles were synthesized in order to obtain new compounds with potential analgesic activity. Compounds were evaluated for their analgesic activities by formalin-induced nociception test. Mefenamic acid (as the reference drug) did not show any activity in the early phase of the formalin test, while compounds 7b, 7c, 8c, and 9a significantly reduced the nociception in this phase. However in the late phase of formalin test all of the target compounds and mefenamic acid showed analgesic activity in comparison to control.

引用

页码：435 / 442

页数：8

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