Multi-protein complexes as drug targets

被引：4
|
作者：
Gestwicki, Jason E. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Pharmaceut Chem, Inst Neurodegenerat Dis, San Francisco, CA 94158 USA
来源：
CELL CHEMICAL BIOLOGY | 2022年 / 29卷 / 05期
关键词：
DNAK;
D O I：
10.1016/j.chembiol.2022.05.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The molecular chaperone DnaK, is an attractive drug target for treating mycobacterial infections. In this issue, Hosfelt, Richards, and colleagues applied a high-throughput screen and discovered inhibitors that disrupt cofactor-mediated activation of DnaK. These inhibitors can lower bacterial survival under stress and decrease resistance to key antibiotics.
引用
收藏
页码：713 / 715
页数：3
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