Multi-protein complexes as drug targets

被引：4

作者：

Gestwicki, Jason E. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pharmaceut Chem, Inst Neurodegenerat Dis, San Francisco, CA 94158 USA

来源：

CELL CHEMICAL BIOLOGY | 2022年 / 29卷 / 05期

关键词：

DNAK;

D O I：

10.1016/j.chembiol.2022.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular chaperone DnaK, is an attractive drug target for treating mycobacterial infections. In this issue, Hosfelt, Richards, and colleagues applied a high-throughput screen and discovered inhibitors that disrupt cofactor-mediated activation of DnaK. These inhibitors can lower bacterial survival under stress and decrease resistance to key antibiotics.

引用

页码：713 / 715

页数：3

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