Evaluation of a PCR-based universal heteroduplex generator assay as a tool for rapid detection of multidrug-resistant Mycobacterium tuberculosis in Peru

被引：11

作者：

Mayta, H

Gilman, RH

Arenas, F

Valencia, T

Caviedes, L

Montenegro, SH

Ticona, E

Ortiz, J

Chumpitaz, R

Evans, CA

Williams, DL

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Internal Hlth, Baltimore, MD 21205 USA

[2] Univ Peruana Cayetano Heredia, Dept Microbiol, Lima, Peru

[3] Maria Auxiliadora Hosp, Lima, Peru

[4] Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England

[5] Ochsner Med Fdnt, New Orleans, LA USA

[6] LSU SVM, Natl Hansens Dis Program, Lab Res Branch, Baton Rouge, LA USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2003年 / 41卷 / 12期

关键词：

D O I：

10.1128/JCM.41.12.5774-5777.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Multidrug-resistant tuberculosis is an increasing health problem worldwide, especially in developing countries. The PCR-UHG-Rif assay, which detects mutations within the rpoB gene associated with rifampin resistance, was evaluated for its ability and reliability to detect and identify drug-resistant Mycobacterium tuberculosis in a developing country where tuberculosis is highly endemic.

引用

页码：5774 / 5777

页数：4

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