Unusual peptides containing the 2,6-diaminopimelic acid framework: Stereocontrolled synthesis, X-ray analysis, and computational modelling. Part 2

被引:19
|
作者
Galeazzi, R
Garavelli, M
Grandi, A
Monari, M
Porzi, G
Sandri, S
机构
[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy
[2] Univ Ancona, Dipartimento Sci Mat & Terra, I-60131 Ancona, Italy
关键词
D O I
10.1016/S0957-4166(03)00541-X
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The stereocontrolled synthesis of peptides 6, 9 and 14, structural variants of 2,6-diaminopimelic acid, was carried out starting from the chiral synthon 1. easily obtained from L-valine. The configuration of the introduced stereogenic centres has been assigned on the basis of H-1 NMR spectroscopic data. X-Ray crystal structure and conformation analysis of 5 are also reported. (C) 2003 Elsevier Ltd. All rights reserved.
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页码:2639 / 2649
页数:11
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