New iboga-type alkaloids from Ervatamia officinalis and their anti-inflammatory activity

被引：3
|
作者：
Tang, Ben-qin [1 ]
Li, Zi-wei [2 ]
Li, Lin [3 ]
Li, Bao-jing [4 ]
Bian, Ya-qi [3 ]
Yu, Guo-dong [1 ]
Chang, Yu [2 ]
Lee, Simon Ming-yuen [3 ]
Zhang, Xiao-qi [2 ]
机构：
[1] Shunde Polytech, Dept Med Sci, Foshan 528333, Peoples R China
[2] Jinan Univ, NMPA Key Lab Qual Evaluat TCM, Guangzhou 510632, Peoples R China
[3] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China
[4] Yunnan Univ Chinese Med, Coll Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China
来源：
FITOTERAPIA | 2022年 / 156卷
基金：
中国国家自然科学基金;
关键词：
Ervatamia officinalis; Iboga-type alkaloids; Anti-inflammatory; Ervaoffines; NO release; MONOTERPENOID INDOLE ALKALOIDS;
D O I：
10.1016/j.fitote.2021.105085
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new iboga-type alkaloids, ervaoffines H-K (1-4), along with five known compounds were obtained from the aerial parts of Ervatamia officinalis. The absolute configurations of 1-4 were confirmed by X-ray diffraction and electronic circular dichroism (ECD) analyses. The isolates were tested for their anti-inflammatory activity. Compounds 1, 5, 6, and 9 showed potential inhibitory effect of NO production in LPS-stimulated BV2 and RAW264.7 cells.
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页数：7
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