CIPROFLOXACIN AND NORFLOXACIN SPECTROPHOTOMETRIC DETERMINATION IN A FULLY AUTOMATED MULTI-PUMPING FLOW SYSTEM

被引：8
|
作者：
Amorim, M. Helena R. [1 ]
Marques, Karine L. [1 ]
Santos, Joao L. M. [1 ]
Lima, Jose L. F. C. [1 ]
机构：
[1] Univ Porto, Fac Farm, Dept Quim, REQUIMTE, P-4099030 Oporto, Portugal
来源：
ANALYTICAL LETTERS | 2011年 / 44卷 / 12期
关键词：
Ciprofloxacin; Multi-pumping; Norfloxacin; Pulsed flow; Spectrophotometry; CHEMILUMINESCENCE DETERMINATION; FLUORESCENCE DETECTION; BIOLOGICAL-FLUIDS; ELECTROGENERATED CHEMILUMINESCENCE; INJECTION CHEMILUMINESCENCE; FLUOROQUINOLONE DERIVATIVES; PHARMACEUTICAL-PREPARATIONS; LIQUID-CHROMATOGRAPHY; DRUG FORMULATIONS; ANTIBIOTICS;
D O I：
10.1080/00032719.2010.546018
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A flow-based methodology for the spectrophotometric determination of ciprofloxacin and norfloxacin, based on the oxidation with N-bromosuccinimide in acidic medium, was developed. The proposed procedure was implemented in a multi-pumping flow system, which provided excellent mixing conditions due to the pulsed flow produced by solenoid micro-pumps actuation, resulting on a sensitive, simple, fast, and versatile analytical method. Linear calibration plots were obtained for ciprofloxacin and norfloxacin concentrations ranging from 5 to 70 mg L(-1) with an R.S.D < 2.2% (n=10). Detection limits (3 sigma) were 0.27 mg L(-1) and 0.99 mg L(-1) for norfloxacin and ciprofloxacin, respectively.
引用
收藏
页码：2074 / 2084
页数：11
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