CIPROFLOXACIN AND NORFLOXACIN SPECTROPHOTOMETRIC DETERMINATION IN A FULLY AUTOMATED MULTI-PUMPING FLOW SYSTEM

被引：8

作者：

Amorim, M. Helena R. ^{[1
]}

Marques, Karine L. ^{[1
]}

Santos, Joao L. M. ^{[1
]}

Lima, Jose L. F. C. ^{[1
]}

机构：

[1] Univ Porto, Fac Farm, Dept Quim, REQUIMTE, P-4099030 Oporto, Portugal

来源：

ANALYTICAL LETTERS | 2011年 / 44卷 / 12期

关键词：

Ciprofloxacin; Multi-pumping; Norfloxacin; Pulsed flow; Spectrophotometry; CHEMILUMINESCENCE DETERMINATION; FLUORESCENCE DETECTION; BIOLOGICAL-FLUIDS; ELECTROGENERATED CHEMILUMINESCENCE; INJECTION CHEMILUMINESCENCE; FLUOROQUINOLONE DERIVATIVES; PHARMACEUTICAL-PREPARATIONS; LIQUID-CHROMATOGRAPHY; DRUG FORMULATIONS; ANTIBIOTICS;

D O I：

10.1080/00032719.2010.546018

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A flow-based methodology for the spectrophotometric determination of ciprofloxacin and norfloxacin, based on the oxidation with N-bromosuccinimide in acidic medium, was developed. The proposed procedure was implemented in a multi-pumping flow system, which provided excellent mixing conditions due to the pulsed flow produced by solenoid micro-pumps actuation, resulting on a sensitive, simple, fast, and versatile analytical method. Linear calibration plots were obtained for ciprofloxacin and norfloxacin concentrations ranging from 5 to 70 mg L(-1) with an R.S.D < 2.2% (n=10). Detection limits (3 sigma) were 0.27 mg L(-1) and 0.99 mg L(-1) for norfloxacin and ciprofloxacin, respectively.

引用

页码：2074 / 2084

页数：11

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