Analysis of IMPACT: is one blood eosinophil count measurement sufficient to predict ICS treatment response in COPD?

被引:2
|
作者
Bafadhel, Mona [1 ]
Barnes, Neil [2 ,3 ]
Bourke, Stephen [4 ,5 ]
Compton, Chris [2 ]
Criner, Gerard [6 ]
Dransfield, Mark [7 ]
Halpin, David [8 ]
Han, Meilan [9 ]
Hartley, Benjamin [10 ]
Jones, C. Elaine [11 ]
Lange, Peter [12 ,13 ]
Lettis, Sally [14 ]
Lipson, David [15 ,16 ]
Lomas, David [17 ]
Martin, Neil [2 ,18 ]
Martinez, Fernando [19 ]
Van der Valk, Ralf [2 ]
Wise, Robert [20 ]
Singh, David [21 ]
机构
[1] Univ Oxford, Nuffield Dept Med, Oxford, England
[2] GlaxoSmithKline, Brentford, England
[3] Barts & London Queen Marys Sch Med & Dent, London, England
[4] North Tyneside Gen Hosp, North Shields, England
[5] Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England
[6] Temple Univ, Lewis Katz Sch Med, Philadelphia, PA 19122 USA
[7] Univ Alabama Birmingham, Lung Hlth Ctr, Div Pulm Allergy & Crit Care Med, Birmingham, AL USA
[8] Royal Devon & Exeter Hosp, Dept Resp Med, Exeter, Devon, England
[9] Univ Michigan, Pulm & Crit Care, Ann Arbor, MI 48109 USA
[10] Veramed Ltd, Twickenham, England
[11] GlaxoSmithKline, Res Triangle Pk, NC USA
[12] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark
[13] Herlev & Gentofte Hosp, Dept Med, Herlev, Denmark
[14] GlaxoSmithKline, Uxbridge, Middx, England
[15] GlaxoSmithKline, Collegeville, PA USA
[16] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
[17] UCL, UCL Resp, London, England
[18] Univ Leicester, Leicester, Leics, England
[19] New York Presbyterian Weill Cornell Med Ctr, New York, NY USA
[20] Johns Hopkins Med, Div Pulm & Crit Care Med, Baltimore, MD USA
[21] Univ Manchester, Manchester, Lancs, England
关键词
D O I
10.1183/13993003.congress-2019.OA260
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
OA260
引用
收藏
页数:3
相关论文
共 47 条
  • [21] Late Breaking Abstract - Blood eosinophil count and exacerbation history in COPD: pooled analysis of 24,103 patients
    Wedzicha, Jadwiga
    Siddiqui, Salman
    Calverley, Peter
    De la Hoz, Alberto
    Voss, Florian
    Magnussen, Helgo
    Rabe, Klaus F.
    Singh, Dave
    EUROPEAN RESPIRATORY JOURNAL, 2019, 54
  • [22] Blood immunoglobulin E and eosinophil levels predict treatment response to omalizumab in refractory chronic urticaria
    Shin, B.
    Kwon, H-S
    Park, S. Y.
    Yoon, S-Y
    Kim, T-B
    Cho, Y. S.
    Moon, H-B
    ALLERGY, 2013, 68 : 36 - 36
  • [23] Response to omalizumab treatment according to blood eosinophil count: Results of a French real-world study (STELLAIR)
    Humbert, Marc
    Mala, Laurence
    Molimard, Mathieu
    EUROPEAN RESPIRATORY JOURNAL, 2017, 50
  • [24] Comparison of the peripheral blood eosinophil count using near-patient testing and standard automated laboratory measurement in healthy, asthmatic and COPD subjects
    Hambleton, Kirsty
    Connolly, Clare M.
    Borg, Catherine
    Davies, Joanne H.
    Jeffers, Helen P.
    Russell, Richard E. K.
    Bafadhel, Mona
    INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2017, 12 : 2771 - 2775
  • [25] Economic benefit of fluticasone furoate (FF)/umeclidinium (UMEC)/vilanterol (VI) by baseline blood eosinophil (EOS) count in COPD in the UK - The IMPACT trial
    Ismaila, Afisi S.
    Shah, Dhvani
    Martin, Alan
    Kendall, Robyn
    Noorduyn, Stephen G.
    Dasari, Priyadarsini
    Risebrough, Nancy A.
    Compton, Chris
    Noorduyn, Stephen G.
    EUROPEAN RESPIRATORY JOURNAL, 2023, 62
  • [26] Parasite-specific IgG response and peripheral blood eosinophil count following albendazole treatment for presumed chronic strongyloidiasis
    Karunajeewa, H
    Kelly, H
    Leslie, D
    Leydon, J
    Saykao, P
    Biggs, BA
    JOURNAL OF TRAVEL MEDICINE, 2006, 13 (02) : 84 - 91
  • [27] RESPONSE TO OMALIZUMAB TREATMENT ACCORDING TO PRE-TREATMENT BLOOD EOSINOPHIL COUNT: RESULTS OF A FRENCH REAL-WORLD STUDY (STELLAIR)
    Humbert, Marc
    Molimard, Mathieu
    Mala, Laurence
    Gavornikova, Marcela
    RESPIROLOGY, 2017, 22 : 169 - 169
  • [28] Association between ICS treatment and blood eosinophil level with interval between severe exacerbation events among COPD patients in Malaysia: EXACOS-MY study
    Musa, Aisya Natasya
    Ismail, Ahmad Izuanuddin
    Aflah, Syazatul Syakirin Sirol
    Wong, Chee Kuan
    RESPIROLOGY, 2024, 29 : 157 - 157
  • [29] Blood Eosinophil Count and Fractional Exhaled Nitric Oxide as a Combined Predictor of Treatment Response to Benralizumab for Patients with Severe, Eosinophilic Asthma
    Katial, R.
    Kreindler, J.
    Hirsch, I
    Newbold, P.
    Gil, Garcia E. G.
    PNEUMOLOGIE, 2021, 75 : S34 - S34
  • [30] Change in blood eosinophils following treatment with inhaled corticosteroids may predict long-term clinical response in COPD
    Mathioudakis, Alexander G.
    Bikov, Andras
    Foden, Philip
    Lahousse, Lies
    Brusselle, Guy
    Singh, Dave
    Vestbo, Jorgen
    EUROPEAN RESPIRATORY JOURNAL, 2020, 55 (05)