Sonic Hedgehog pathway activity in prostate cancer

被引：13

作者：

Bragina, Olga ^{[1
]}

Njunkova, Natalja ^{[4
]}

Sergejeva, Svetlana ^{[2
]}

Jarvekulg, Lilian ^{[3
,5
]}

Kogerman, Priit ^{[1
,3
,5
]}

机构：

[1] Tallinn Univ Technol, Dept Oncol, Inst Clin Med, Tallinn, Estonia

[2] Tallinn Univ Technol, Dept Clin Med, Inst Clin Med, Tallinn, Estonia

[3] Tallinn Univ Technol, Dept Gene Technol, Div Mol Diagnost, Tallinn, Estonia

[4] Cent Lab Communicable Dis, Hlth Protect Inspectorate, Tallinn, Estonia

[5] Competence Ctr Canc Res, Tallinn, Estonia

来源：

ONCOLOGY LETTERS | 2010年 / 1卷 / 02期

基金：

英国惠康基金;

关键词：

transgenic adenocarcinoma of the mouse prostate; mice; immunohistochemistry; DOWN-REGULATION; KRUPPEL FAMILY; PROLIFERATION; EXPRESSION; INTERFERENCE; PROGRESSION; INHIBITION; ACTIVATION; PROMOTER; CELLS;

D O I：

10.3892/ol_00000057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Abnormal activation of the Sonic hedgehog (Shh) signaling pathway has been demonstrated in a number of human tumors, including prostate cancer The study aimed to assess the activity of Shh pathway components (Shh, Gli1, Gli2 and Gli3), as well as the proliferation markers FoxAl and Notch1 during cancer progression in the transgenic adenocarcinoma of the mouse prostate (TRAMP) We evaluated changes in respective proteins by immunohistochemistry at three time points (12, 17 and 21 weeks of age) in the tissue of TRAMP and C57Bl/6 mice Moreover, the expression of mRNA of these proteins was assessed The present study shows a significant age-dependent increase in the number of Shh, Glil1, Gli3 and FoxAl-positive prostate cells and a decrease in Gli2-positive cells in TRAMP The study also supports the hypothesis that the development of prostate cancer and its metastasis is associated with activation of the Shh signaling pathway

引用

页码：319 / 325

页数：7

共 50 条

[41] Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer
Suzman, Daniel L.
Antonarakis, Emmanuel S.
CANCERS, 2015, 7 (04): : 1983 - 1993
[42] Sonic hedgehog signaling involved in prostate cancer metastasis and can be blocked by cyclopamine
不详
CANCER BIOLOGY & THERAPY, 2004, 3 (10) : 926 - 926
[43] Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation
Zunich, Samantha M.
Douglas, Taneka
Valdovinos, Maria
Chang, Tiffany
Bushman, Wade
Walterhouse, David
Iannaccone, Philip
Lamm, Marilyn L. G.
MOLECULAR CANCER, 2009, 8
[44] Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation
Samantha M Zunich
Taneka Douglas
Maria Valdovinos
Tiffany Chang
Wade Bushman
David Walterhouse
Philip Iannaccone
Marilyn LG Lamm
Molecular Cancer, 8
[45] Sonic Hedgehog Signalling Pathway and Ameloblastoma - A Review
Mishra, Pallavi
Panda, Abikshyeet
Bandyopadhyay, Alokenath
Kumar, Harish
Mohiddin, Gouse
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2015, 9 (11) : ZE10 - ZE13
[46] Sonic Hedgehog pathway is upregulated in adamantinomatous craniopharyngiomas
Gomes, D. C.
Jamra, S. A.
Leal, L. F.
Colli, L. M.
Campanini, M. L.
Oliveira, R. S.
Martinelli, C. E., Jr.
Elias, P. C. L.
Moreira, A. C.
Machado, H. R.
Saggioro, F.
Neder, L.
Castro, M.
Antonini, S. R.
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2015, 172 (05) : 603 - 608
[47] SONIC HEDGEHOG PATHWAY IS ACTIVE IN HUMAN PENIS
Angeloni, N. L.
Bond, C. W.
McVary, K. T.
Podlasek, C. A.
JOURNAL OF SEXUAL MEDICINE, 2012, 9 : 273 - 273
[48] Role of the Sonic Hedgehog pathway in thoracic cancers
Leprieur, E. Giroux
Antoine, M.
Vieira, T.
Rozensztajn, N.
Ruppert, A. -M.
Rabbe, N.
Cadranel, J.
Wislez, M.
REVUE DES MALADIES RESPIRATOIRES, 2015, 32 (08) : 800 - 808
[49] Targeting the sonic hedgehog pathway in paediatric malignancies
Geoerger, B.
EUROPEAN JOURNAL OF CANCER, 2013, 49 : S74 - S74
[50] Human developmental disorders and the Sonic hedgehog pathway
Ming, JE
Roessler, E
Muenke, M
MOLECULAR MEDICINE TODAY, 1998, 4 (08): : 343 - 349

← 1 2 3 4 5 →