Sonic Hedgehog pathway activity in prostate cancer

被引：13
|
作者：
Bragina, Olga [1 ]
Njunkova, Natalja [4 ]
Sergejeva, Svetlana [2 ]
Jarvekulg, Lilian [3 ,5 ]
Kogerman, Priit [1 ,3 ,5 ]
机构：
[1] Tallinn Univ Technol, Dept Oncol, Inst Clin Med, Tallinn, Estonia
[2] Tallinn Univ Technol, Dept Clin Med, Inst Clin Med, Tallinn, Estonia
[3] Tallinn Univ Technol, Dept Gene Technol, Div Mol Diagnost, Tallinn, Estonia
[4] Cent Lab Communicable Dis, Hlth Protect Inspectorate, Tallinn, Estonia
[5] Competence Ctr Canc Res, Tallinn, Estonia
来源：
ONCOLOGY LETTERS | 2010年 / 1卷 / 02期
基金：
英国惠康基金;
关键词：
transgenic adenocarcinoma of the mouse prostate; mice; immunohistochemistry; DOWN-REGULATION; KRUPPEL FAMILY; PROLIFERATION; EXPRESSION; INTERFERENCE; PROGRESSION; INHIBITION; ACTIVATION; PROMOTER; CELLS;
D O I：
10.3892/ol_00000057
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Abnormal activation of the Sonic hedgehog (Shh) signaling pathway has been demonstrated in a number of human tumors, including prostate cancer The study aimed to assess the activity of Shh pathway components (Shh, Gli1, Gli2 and Gli3), as well as the proliferation markers FoxAl and Notch1 during cancer progression in the transgenic adenocarcinoma of the mouse prostate (TRAMP) We evaluated changes in respective proteins by immunohistochemistry at three time points (12, 17 and 21 weeks of age) in the tissue of TRAMP and C57Bl/6 mice Moreover, the expression of mRNA of these proteins was assessed The present study shows a significant age-dependent increase in the number of Shh, Glil1, Gli3 and FoxAl-positive prostate cells and a decrease in Gli2-positive cells in TRAMP The study also supports the hypothesis that the development of prostate cancer and its metastasis is associated with activation of the Shh signaling pathway
引用
收藏
页码：319 / 325
页数：7
相关论文
共 50 条
  • [31] Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway
    Subramani, Ramadevi
    Gonzalez, Elizabeth
    Nandy, Sushmita Bose
    Arumugam, Arunkumar
    Camacho, Fernando
    Medel, Joshua
    Alabi, Damilola
    Lakshmanaswamy, Rajkumar
    ONCOTARGET, 2017, 8 (07) : 10891 - 10904
  • [32] Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli
    Wang, Zhong Chuan
    Gao, Jun
    Zi, Shu Ming
    Yang, Ming
    Du, Peng
    Cui, Long
    JOURNAL OF DIGESTIVE DISEASES, 2013, 14 (08) : 417 - 424
  • [33] Sonic Hedgehog Pathway Contributes to Gastric Cancer Cell Growth and Proliferation
    Wan, Jianhua
    Zhou, Ji
    Zhao, Hailong
    Wang, Mei
    Wei, Zhuanqin
    Gao, Hongyan
    Wang, Yongzhong
    Cui, Hongjuan
    BIORESEARCH OPEN ACCESS, 2014, 3 (02): : 53 - 59
  • [34] Hedgehog pathway activity in the LADY prostate tumor model
    Jerry Gipp
    Guangyu Gu
    Curtis Crylen
    Susan Kasper
    Wade Bushman
    Molecular Cancer, 6
  • [35] Hedgehog pathway activity in the LADY prostate tumor model
    Gipp, Jerry
    Gu, Guangyu
    Crylen, Curtis
    Kasper, Susan
    Bushman, Wade
    MOLECULAR CANCER, 2007, 6 (1)
  • [36] Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway
    Cai, Maoping
    Ge, Shengdong
    Hong, Yaying
    Chen, Yao
    Ren, Yang-Zi
    Zhong, Dacai
    Chen, Mingkun
    Liu, Yuan
    Chen, Zhe-Sheng
    Feng, Ninghan
    Chen, Zhanghui
    Zhao, Shan-Chao
    MOLECULAR MEDICINE, 2025, 31 (01)
  • [37] Sonic Hedgehog Signaling Pathway Supports Cancer Cell Growth during Cancer Radiotherapy
    Ma, Jingjing
    Tian, Ling
    Cheng, Jin
    Chen, Zhiwei
    Xu, Bing
    Wang, Liwei
    Li, Chuanyuan
    Huang, Qian
    PLOS ONE, 2013, 8 (06):
  • [38] Interaction of sonic hedgehog (SHH) pathway with cancer stem cell genes in gastric cancer
    Ali Akbar Samadani
    Haleh Akhavan-Niaki
    Medical Oncology, 2015, 32
  • [39] Sonic hedgehog pathway activation increases mitochondrial abundance and activity in hippocampal neurons
    Yao, Pamela J.
    Manor, Uri
    Petralia, Ronald S.
    Brose, Rebecca D.
    Wu, Ryan T. Y.
    Ott, Carolyn
    Wang, Ya-Xian
    Charnoff, Ari
    Lippincott-Schwartz, Jennifer
    Mattson, Mark P.
    MOLECULAR BIOLOGY OF THE CELL, 2017, 28 (03) : 387 - 395
  • [40] Interaction of sonic hedgehog (SHH) pathway with cancer stem cell genes in gastric cancer
    Samadani, Ali Akbar
    Akhavan-Niaki, Haleh
    MEDICAL ONCOLOGY, 2015, 32 (03)
12345