Bhlhe40: Gatekeeper of the GC

被引：1
|
作者：
Nutt, Stephen L. [1 ,2 ]
Tellier, Julie [1 ,2 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia
[2] Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 2021年 / 219卷 / 02期
关键词：
D O I：
10.1084/jem.20212333
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The generation of high-affinity antibodies in the germinal center (GC) requires interplay between GC B cells and T follicular helper cells. Rauschmeier et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211406) report that Bhlhe40 restrains GC output through distinct regulatory roles in both arms of the response.
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