The Evi1, microRNA-143, K-Ras axis in colon cancer

被引：25

作者：

Gao, Jin-Song

Zhang, Yingjie

Tang, Xiaoli

Tucker, Lynne D.

Tarwater, Patrick M. ^{[2
]}

Quesenberry, Peter J. ^{[3
]}

Rigoutsos, Isidore ^{[4
]}

Ramratnam, Bharat ^{[1
]}

机构：

[1] Brown Univ, Miriam Isl Hosp, Lab Retrovirol, Dept Med,Div Infect Dis, Providence, RI 02903 USA

[2] Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, Div Biostat, El Paso, TX USA

[3] Brown Univ, Warren Alpert Med Sch, Dept Med, Div Hematol & Oncol, Providence, RI 02903 USA

[4] Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

FEBS LETTERS | 2011年 / 585卷 / 04期

基金：

美国国家卫生研究院;

关键词：

MicroRNA; Evi1; Colon cancer; RNA interference; OVARIAN-CANCER; EXPRESSION; RESISTANCE; REGULATOR;

D O I：

10.1016/j.febslet.2011.01.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：693 / 699

页数：7

共 50 条

[41] MicroRNA-143 (miR-143) Regulates Cancer Glycolysis via Targeting Hexokinase 2 Gene
Fang, Rong
Xiao, Tian
Fang, Zhaoyuan
Sun, Yihua
Li, Fei
Gao, Yijun
Feng, Yan
Li, Li
Wang, Ye
Liu, Xiaolong
Chen, Haiquan
Liu, Xin-Yuan
Ji, Hongbin
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (27) : 23227 - 23235
[42] EVI1 promotes metastasis by downregulating TIMP2 in metastatic colon and breast cancer cells
Pradeepa
Suresh, Voddu
Singh, Vivek Kumar
Nayak, Kasturi Bala
Senapati, Shantibhusan
Chakraborty, Soumen
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2022, 142
[43] Identification of novel SOS1-K-Ras disruptors for NSCLC and colon cancers with K-Ras mutation.
Sasmal, Sanjita
Ramanathan, Anuradha
Boorgu, Venkatesham
CANCER RESEARCH, 2021, 81 (13)
[44] Association of K-ras mutations with p16 methylation in human colon cancer
Guan, RJ
Fu, YN
Holt, PR
Pardee, AB
GASTROENTEROLOGY, 1999, 116 (05) : 1063 - 1071
[45] Does Mutated K-RAS Oncogene Attenuate the Effect of Sulindac in Colon Cancer Chemoprevention?
Rice, Photini F. S.
Ehrichs, Kevin G.
Jones, Mykella S.
Chen, Hwudarw
Hsu, Chiu-Hsieh
Abril, Edward R.
Nagle, Raymond B.
Besselsen, David G.
Barton, Jennifer K.
Ignatenko, Natalia A.
CANCER PREVENTION RESEARCH, 2018, 11 (01) : 16 - 26
[46] Association of K-ras mutations with p16 methylation in human colon cancer
Guan, RJ
Fu, Y
Holt, PR
Pardee, AB
GASTROENTEROLOGY, 1999, 116 (04) : A415 - A415
[47] The novel role of K-RAS signaling in the induction of VEGF during hypoxia in colon cancer
Mizukami, Yusuke
Kohgo, Yutaka
Chung, Daniel C.
CLINICAL & EXPERIMENTAL METASTASIS, 2007, 24 (04) : 232 - 233
[48] IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function
Matsunaga, Hironori
Kubota, Kazuishi
Inoue, Tatsuya
Isono, Fujio
Ando, Osamu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 444 (03) : 360 - 364
[49] microRNA-143/145 loss induces Ras signaling to promote aggressive Pten-deficient basal-like breast cancer
Wang, Sharon
Liu, Jeff C.
Ju, YoungJun
Pellecchia, Giovanna
Voisin, Veronique
Wang, Dong-Yu
Leha, Rajwinder L.
Ben-David, Yaacov
Bader, Gary D.
Zacksenhaus, Eldad
JCI INSIGHT, 2017, 2 (15):
[50] K-RAS MUTATIONS IN PUTATIVE PRENEOPLASTIC LESIONS IN HUMAN COLON
PRETLOW, TP
BRASITUS, TA
FULTON, NC
CHEYER, C
KAPLAN, EL
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (24) : 2004 - 2007

← 1 2 3 4 5 →