The Evi1, microRNA-143, K-Ras axis in colon cancer

被引：25

作者：

Gao, Jin-Song

Zhang, Yingjie

Tang, Xiaoli

Tucker, Lynne D.

Tarwater, Patrick M. ^{[2
]}

Quesenberry, Peter J. ^{[3
]}

Rigoutsos, Isidore ^{[4
]}

Ramratnam, Bharat ^{[1
]}

机构：

[1] Brown Univ, Miriam Isl Hosp, Lab Retrovirol, Dept Med,Div Infect Dis, Providence, RI 02903 USA

[2] Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, Div Biostat, El Paso, TX USA

[3] Brown Univ, Warren Alpert Med Sch, Dept Med, Div Hematol & Oncol, Providence, RI 02903 USA

[4] Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

FEBS LETTERS | 2011年 / 585卷 / 04期

基金：

美国国家卫生研究院;

关键词：

MicroRNA; Evi1; Colon cancer; RNA interference; OVARIAN-CANCER; EXPRESSION; RESISTANCE; REGULATOR;

D O I：

10.1016/j.febslet.2011.01.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：693 / 699

页数：7

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