The Evi1, microRNA-143, K-Ras axis in colon cancer

被引：25
|
作者：
Gao, Jin-Song
Zhang, Yingjie
Tang, Xiaoli
Tucker, Lynne D.
Tarwater, Patrick M. [2 ]
Quesenberry, Peter J. [3 ]
Rigoutsos, Isidore [4 ]
Ramratnam, Bharat [1 ]
机构：
[1] Brown Univ, Miriam Isl Hosp, Lab Retrovirol, Dept Med,Div Infect Dis, Providence, RI 02903 USA
[2] Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, Div Biostat, El Paso, TX USA
[3] Brown Univ, Warren Alpert Med Sch, Dept Med, Div Hematol & Oncol, Providence, RI 02903 USA
[4] Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
来源：
FEBS LETTERS | 2011年 / 585卷 / 04期
基金：
美国国家卫生研究院;
关键词：
MicroRNA; Evi1; Colon cancer; RNA interference; OVARIAN-CANCER; EXPRESSION; RESISTANCE; REGULATOR;
D O I：
10.1016/j.febslet.2011.01.033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：693 / 699
页数：7
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