Anti-influenza A (H1N1) viral and cytotoxic sesquiterpenes from Carpesium abrotanoides

被引：18

作者：

He, Yu-Qing ^{[1
]}

Cai, Liang ^{[2
]}

Qian, Qun-Gang ^{[1
]}

Yang, Sheng-Hui ^{[1
]}

Chen, Di-Lu ^{[1
]}

Zhao, Bi-Qing ^{[1
]}

Zhong, Zhen-Ping ^{[3
]}

Zhou, Xiao-Jiang ^{[1
]}

机构：

[1] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Peoples R China

[2] Hunan Prov Ctr Dis Control & Prevent, Changsha 410005, Peoples R China

[3] Yao Sheng Tang Hu Nan Pharmaceut Co Ltd, Anxiang 415600, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2020年 / 35卷

基金：

中国国家自然科学基金;

关键词：

Sesquiterpene; Carpesium abrotanoides L; Cytotoxic activity; Anti-influenza A (H1N1) viral activity; CONSTITUENTS; LACTONES; THERAPY;

D O I：

10.1016/j.phytol.2019.10.013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new sesquiterpenes, named carpabrotalactone A (1) and B (2), together with six known sesquiterpenes, 11 (13)-dehydroivaxillin (3), eriolin (4), 2 alpha,5 alpha- dihydroxy-11 alpha H-eudesma-4(15)- en-12,8 beta- olide (5), (5 alpha)-5-hy-droxyasperilin (6), 1 alpha,4 alpha-dihydroxy-guaia-11(13)-ene-12,8 alpha-olide (7) and 4 alpha,5 alpha-dihydroxy-guaia-11(13)-en-12,8 alpha-lactone (8), were isolated from the herbs of Carpesium abrotanoides L. The structures of these sesquiterpenes were elucidated based on spectroscopic analysis, and single crystal X-ray diffraction analysis. All the compounds exhibited potent cytotoxicity against the ISK, Hela, A549, Sw620, RBE and Caco-2 cell lines, with IC50 values ranging from 7.8-47.4 mu M. In addition, compounds 2, 3, 4, 7 and 8 displayed significant anti-influenza A (H1N1) virus activity with IC50, values of 6.2, 11.6, 16.4, 1.3 and 0.4 mu M, respectively.

引用

页码：41 / 45

页数：5

共 50 条

[41] Influenza A (H1N1) and myocarditis
Khambekar, S. K.
Harden, S.
Corbett, S.
HEART, 2011, 97 (19) : 1630 - 1630
[42] Pandemic H1N1 influenza
Wiwanitkit, Viroj
SAUDI MEDICAL JOURNAL, 2010, 31 (12) : 1380 - 1380
[43] Influenza A/H1N1 2009
不详
TRAVEL MEDICINE AND INFECTIOUS DISEASE, 2010, 8 (01) : 60 - 60
[44] CORTICOSTEROIDS IN INFLUENZA A/H1N1
Ben Saida, I.
Khedher, A.
Ayechi, J.
Chahed, R.
Hachfi, W.
Dammak, H.
Abdelghani, A.
Boussarsar, M.
INTENSIVE CARE MEDICINE, 2013, 39 : S380 - S381
[45] 2009 H1N1 Influenza
Sullivan, Seth J.
Jacobson, Robert M.
Dowdle, Walter R.
Poland, Gregory A.
MAYO CLINIC PROCEEDINGS, 2010, 85 (01) : 64 - 76
[46] Pandemic Influenza A (H1N1)
Bazak Sharon
Mark R Schleiss
Pediatric Research, 2009, 66 : 599 - 599
[47] Swine Influenza A (H1N1)
AlKhawaja, Safaa
BAHRAIN MEDICAL BULLETIN, 2009, 31 (02)
[48] 2009 H1N1 Influenza
Sullivan, Seth J.
Jacobson, Robert M.
Dowdle, Walter R.
Poland, Gregory A.
MEDISUR-REVISTA DE CIENCIAS MEDICAS DE CIENFUEGOS, 2010, 8 (01): : 68 - 80
[49] Pandemic Influenza A (H1N1)
Sharon, Bazak
Schleiss, Mark R.
PEDIATRIC RESEARCH, 2009, 66 (06) : 599 - 599
[50] Monovalent Influenza A (H1N1)
不详
FUTURE VIROLOGY, 2009, 4 (06) : 523 - 523

← 1 2 3 4 5 →