Anti-influenza A (H1N1) viral and cytotoxic sesquiterpenes from Carpesium abrotanoides

被引：18
|
作者：
He, Yu-Qing [1 ]
Cai, Liang [2 ]
Qian, Qun-Gang [1 ]
Yang, Sheng-Hui [1 ]
Chen, Di-Lu [1 ]
Zhao, Bi-Qing [1 ]
Zhong, Zhen-Ping [3 ]
Zhou, Xiao-Jiang [1 ]
机构：
[1] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Peoples R China
[2] Hunan Prov Ctr Dis Control & Prevent, Changsha 410005, Peoples R China
[3] Yao Sheng Tang Hu Nan Pharmaceut Co Ltd, Anxiang 415600, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2020年 / 35卷
基金：
中国国家自然科学基金;
关键词：
Sesquiterpene; Carpesium abrotanoides L; Cytotoxic activity; Anti-influenza A (H1N1) viral activity; CONSTITUENTS; LACTONES; THERAPY;
D O I：
10.1016/j.phytol.2019.10.013
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new sesquiterpenes, named carpabrotalactone A (1) and B (2), together with six known sesquiterpenes, 11 (13)-dehydroivaxillin (3), eriolin (4), 2 alpha,5 alpha- dihydroxy-11 alpha H-eudesma-4(15)- en-12,8 beta- olide (5), (5 alpha)-5-hy-droxyasperilin (6), 1 alpha,4 alpha-dihydroxy-guaia-11(13)-ene-12,8 alpha-olide (7) and 4 alpha,5 alpha-dihydroxy-guaia-11(13)-en-12,8 alpha-lactone (8), were isolated from the herbs of Carpesium abrotanoides L. The structures of these sesquiterpenes were elucidated based on spectroscopic analysis, and single crystal X-ray diffraction analysis. All the compounds exhibited potent cytotoxicity against the ISK, Hela, A549, Sw620, RBE and Caco-2 cell lines, with IC50 values ranging from 7.8-47.4 mu M. In addition, compounds 2, 3, 4, 7 and 8 displayed significant anti-influenza A (H1N1) virus activity with IC50, values of 6.2, 11.6, 16.4, 1.3 and 0.4 mu M, respectively.
引用
收藏
页码：41 / 45
页数：5
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